Detailed information for compound 379345

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1269.48 | Formula: C56H88N18O14S
  • H donors: 18 H acceptors: 15 LogP: -3.76 Rotable bonds: 52
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCCC(C(=O)NCC(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)N)CCSC)CC(C)C)Cc1nc[nH]c1)C(C)C)C)Cc1c[nH]c2c1cccc2)CCC(=O)N)CO)N
  • InChi: 1S/C56H88N18O14S/c1-29(2)19-39(54(86)71-37(48(60)80)16-18-89-6)72-55(87)41(21-33-23-61-28-66-33)69-45(78)26-65-56(88)47(30(3)4)74-49(81)31(5)67-53(85)40(20-32-22-62-36-13-8-7-11-34(32)36)73-52(84)38(14-15-43(59)76)68-44(77)25-64-51(83)42(27-75)70-46(79)24-63-50(82)35(58)12-9-10-17-57/h7-8,11,13,22-23,28-31,35,37-42,47,62,75H,9-10,12,14-21,24-27,57-58H2,1-6H3,(H2,59,76)(H2,60,80)(H,61,66)(H,63,82)(H,64,83)(H,65,88)(H,67,85)(H,68,77)(H,69,78)(H,70,79)(H,71,86)(H,72,87)(H,73,84)(H,74,81)
  • InChiKey: UNFXPPKALMHWIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2158 1 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.1291 0.3287 0.3287
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2158 1 1
Brugia malayi SH2 domain containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0867 0 0.5
Echinococcus granulosus SH2 motif 0.1291 0.3287 0.3287
Schistosoma mansoni tyrosine kinase 0.2158 1 1
Echinococcus multilocularis N chimaerin 0.1291 0.3287 0.3287
Leishmania major protein kinase, putative 0.0867 0 0.5
Brugia malayi SH2 domain containing protein 0.1291 0.3287 0.3287
Schistosoma mansoni tyrosine kinase 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.1291 0.3287 0.3287
Echinococcus granulosus suppressor of cytokine signaling 6 0.1291 0.3287 0.3287
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0867 0 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.2158 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0867 0 0.5
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1291 0.3287 0.3287
Brugia malayi RhoGAP domain containing protein 0.1291 0.3287 0.3287
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0867 0 0.5
Brugia malayi hypothetical protein 0.1291 0.3287 0.3287
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1291 0.3287 0.3287
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0867 0 0.5
Brugia malayi SH2 domain containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1291 0.3287 0.3287
Schistosoma mansoni hypothetical protein 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein kinase Srms 0.2158 1 1
Echinococcus granulosus tensin 0.1291 0.3287 0.3287
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Brugia malayi STAT protein, DNA binding domain containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1291 0.3287 0.3287
Echinococcus granulosus hypothetical protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) TK protein kinase 0.2158 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1291 0.3287 0.3287
Onchocerca volvulus 0.1291 0.3287 0.3287
Loa Loa (eye worm) hypothetical protein 0.2158 1 1
Schistosoma mansoni tyrosine kinase 0.2158 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.2158 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1291 0.3287 0.3287
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1291 0.3287 0.3287
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1291 0.3287 0.3287
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2158 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus granulosus N chimaerin 0.1291 0.3287 0.3287
Brugia malayi SH2 domain containing protein 0.2158 1 1
Echinococcus granulosus SHC transforming protein 3 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein kinase Src42A 0.2158 1 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.2158 1 1
Echinococcus granulosus SH2 domain containing protein 7 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus granulosus SH2 motif 0.1291 0.3287 0.3287
Schistosoma mansoni tensin 0.1291 0.3287 0.3287
Trichomonas vaginalis conserved hypothetical protein 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trypanosoma cruzi protein kinase, putative 0.0867 0 0.5
Echinococcus multilocularis NCK adaptor protein 0.1291 0.3287 0.3287
Echinococcus multilocularis SHC transforming protein 3 0.1291 0.3287 0.3287
Brugia malayi Variant SH3 domain containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Plasmodium falciparum protein kinase, putative 0.0867 0 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis tensin 0.1291 0.3287 0.3287
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein kinase Lyn 0.2158 1 1
Brugia malayi SH2 domain containing protein 0.1291 0.3287 0.3287
Schistosoma mansoni suppressor of cytokine signaling 0.1291 0.3287 0.3287
Trichomonas vaginalis TK family protein kinase 0.0867 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0867 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Toxoplasma gondii protein kinase domain-containing protein 0.0867 0 0.5
Schistosoma mansoni tensin-related 0.1291 0.3287 0.3287
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Brugia malayi Protein kinase domain containing protein 0.2158 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Trichomonas vaginalis STE family protein kinase 0.0867 0 0.5
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0867 0 0.5
Schistosoma mansoni tyrosine kinase 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2158 1 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.1291 0.3287 0.3287
Plasmodium falciparum protein kinase, putative 0.0867 0 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.0867 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2158 1 1
Echinococcus granulosus tyrosine protein kinase shark 0.2158 1 1
Echinococcus granulosus expressed conserved protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine kinase 0.2158 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Entamoeba histolytica SH2 domain containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis tyrosine kinase 0.2158 1 1
Trichomonas vaginalis AGC family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Echinococcus multilocularis tensin 0.1291 0.3287 0.3287
Onchocerca volvulus 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Brugia malayi Variant SH3 domain containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis signal transduction protein lnk realted 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Schistosoma mansoni tensin 0.1291 0.3287 0.3287
Schistosoma mansoni growth factor receptor-bound protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) SH2 domain-containing protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2158 1 1
Toxoplasma gondii protein kinase 0.0867 0 0.5
Echinococcus multilocularis SH2 motif 0.1291 0.3287 0.3287
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Giardia lamblia Kinase 0.0867 0 0.5
Trichomonas vaginalis protein kinase atn1, putative 0.0867 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Echinococcus multilocularis c src tyrosine kinase 0.2158 1 1
Echinococcus granulosus NCK adaptor protein 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein kinase Src64B 0.2158 1 1
Echinococcus multilocularis SH2 domain containing protein 7 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Plasmodium falciparum tyrosine kinase-like protein 0.0867 0 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2158 1 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2158 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2158 1 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2158 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.2158 1 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1291 0.3287 0.3287
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein kinase Src42A 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2158 1 1
Onchocerca volvulus 0.1291 0.3287 0.3287
Onchocerca volvulus 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0867 0 0.5
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni nck2/grb4 0.1291 0.3287 0.3287
Leishmania major protein kinase, putative 0.0867 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein kinase Fyn 0.2158 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1291 0.3287 0.3287
Brugia malayi Protein kinase domain containing protein 0.2158 1 1
Brugia malayi SH2 domain containing protein 0.1291 0.3287 0.3287
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1291 0.3287 0.3287
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0867 0 0.5
Onchocerca volvulus 0.2158 1 1
Trypanosoma brucei Pseudokinase, putative 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis protein tyrosine kinase, putative 0.0867 0 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.1291 0.3287 0.3287
Entamoeba histolytica protein kinase, putative 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trypanosoma brucei Flagellum attachment zone protein 20 0.0867 0 0.5
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1291 0.3287 0.3287
Schistosoma mansoni GTPase activating protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1291 0.3287 0.3287
Brugia malayi SRC-1 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2158 1 1
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni tensin 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis conserved hypothetical protein 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni tyrosine kinase 0.2158 1 1
Schistosoma mansoni vav2 0.1291 0.3287 0.3287
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0867 0 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Echinococcus granulosus growth factor receptor bound protein 2 0.1291 0.3287 0.3287
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis growth factor receptor bound protein 2 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2158 1 1
Brugia malayi hypothetical protein 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0867 0 0.5
Echinococcus multilocularis SH2 motif 0.1291 0.3287 0.3287
Schistosoma mansoni tensin-related 0.1291 0.3287 0.3287
Echinococcus multilocularis SH2 motif 0.1291 0.3287 0.3287
Onchocerca volvulus 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Brugia malayi SH2 domain containing protein 0.2158 1 1
Brugia malayi protein-tyrosine kinase 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.1291 0.3287 0.3287
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Onchocerca volvulus 0.2158 1 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1291 0.3287 0.3287
Brugia malayi Sex muscle abnormal protein 5 0.1291 0.3287 0.3287
Brugia malayi Protein kinase domain containing protein 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2158 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2158 1 1
Onchocerca volvulus 0.1291 0.3287 0.3287
Echinococcus multilocularis tyrosine protein kinase Abl 0.2158 1 1
Giardia lamblia Kinase, NEK 0.0867 0 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Brugia malayi SH2 domain containing protein 0.1291 0.3287 0.3287
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Onchocerca volvulus 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2158 1 1
Brugia malayi Protein kinase domain containing protein 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis tyrosine protein kinase Blk 0.2158 1 1
Loa Loa (eye worm) TK/ABL protein kinase 0.2158 1 1
Schistosoma mansoni tyrosine kinase 0.2158 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni SH2A 0.1291 0.3287 0.3287
Toxoplasma gondii STE kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1291 0.3287 0.3287
Echinococcus granulosus c src tyrosine kinase 0.2158 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0867 0 0.5
Onchocerca volvulus 0.2158 1 1
Trypanosoma brucei protein kinase, putative 0.0867 0 0.5
Giardia lamblia Kinase, NEK 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0867 0 0.5
Schistosoma mansoni shc transforming protein 0.1291 0.3287 0.3287
Echinococcus multilocularis 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.2158 1 1
Brugia malayi SH2 domain containing protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni hypothetical protein 0.1291 0.3287 0.3287
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2158 1 1
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni adapter molecule crk 0.1291 0.3287 0.3287
Loa Loa (eye worm) STAT protein 0.1291 0.3287 0.3287
Onchocerca volvulus 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1291 0.3287 0.3287
Brugia malayi tRNA modification GTPase TrmE family protein 0.1291 0.3287 0.3287
Plasmodium falciparum tyrosine kinase-like protein 0.0867 0 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1291 0.3287 0.3287
Giardia lamblia Protein 21.1 0.0867 0 0.5
Leishmania major hypothetical protein, conserved 0.0867 0 0.5
Plasmodium falciparum protein kinase, putative 0.0867 0 0.5
Loa Loa (eye worm) SRC-1 0.2158 1 1
Echinococcus granulosus tyrosine kinase 0.2158 1 1
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Trypanosoma cruzi protein kinase, putative 0.0867 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0867 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2158 1 1
Brugia malayi Tensin 0.1291 0.3287 0.3287
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1291 0.3287 0.3287
Onchocerca volvulus 0.2158 1 1
Plasmodium vivax protein kinase, putative 0.0867 0 0.5
Trichomonas vaginalis TKL family protein kinase 0.0867 0 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.1291 0.3287 0.3287
Echinococcus granulosus signal transduction protein lnk realted 0.1291 0.3287 0.3287
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1291 0.3287 0.3287
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1291 0.3287 0.3287

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.8 nM In vitro binding affinity of [111In]-DTPA-[Y4]-bombesin to bombesin receptor in the rat pancreatic acinar cell line, AR42J ChEMBL. 11985468

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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