Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.2519 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.2519 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.2519 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.2519 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.2519 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.2519 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.2519 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.2519 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.2519 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.2519 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.2519 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.2519 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.2519 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.2519 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.2519 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.2519 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.2519 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.2519 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 274 nM | Displacement of [3H]-estradiol from estrogen receptor-ligand binding domain | ChEMBL. | 10476873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.