Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0839 | 0.0151 | 0.0151 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1665 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1665 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1665 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1665 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0826 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1476 | 0.7743 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1665 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1665 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1665 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.1028 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.1665 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1665 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1665 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1665 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.1665 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1665 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.1665 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.1665 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0826 | 0 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.1028 | 0.2407 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1665 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1665 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.1476 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1665 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1665 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1665 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1665 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1665 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 4.419 | Calculated partition coefficient (clogP) | ChEMBL. | 12657285 |
MIC (functional) | = 0.39 ug ml-1 | In vitro antibacterial activity against Pasteurella multocida 59A0067 | ChEMBL. | 12657285 |
MIC (functional) | = 3.13 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus 01A0758 | ChEMBL. | 12657285 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Escherichia coli 51A0150 | ChEMBL. | 12657285 |
MIC (functional) | = 25 ug ml-1 | In vitro antibacterial activity against Escherichia coli 51A0150 | ChEMBL. | 12657285 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.