Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 4 | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
IC50 (binding) | = 5.58 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
IC50 (binding) | = 5.58 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
IC50 (binding) | = 2.63 uM | Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees. | ChEMBL. | 11814774 |
IC50 (binding) | = 2.63 uM | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 9135032 |
IC50 (binding) | = 2.63 uM | Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees. | ChEMBL. | 11814774 |
IC50 (binding) | = 2.63 uM | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 9135032 |
IC50 (binding) | > 100 uM | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 9135032 |
IC50 (binding) | > 100 uM | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 9135032 |
Ki (binding) | = 1.12 | Inhibitory constant against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Ki (binding) | = 1.12 | Inhibitory constant against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Ki (binding) | = 3.41 | Inhibitory constant against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Log IC50 (binding) | < 4 | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 12383007 |
Log IC50 (binding) | = 5.58 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
Log IC50 (binding) | = 5.58 | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 12383007 |
Selectivity (binding) | > 1.58 | Selectivity as log (IC50[COX-1]/IC50[COX-2]). | ChEMBL. | 12383007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.