Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0443 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0443 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0443 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0443 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0443 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0393 | 0.7743 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0443 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0443 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0274 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.022 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0443 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0443 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0443 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0443 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0443 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0443 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0443 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0443 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0274 | 0.2407 | 0.2407 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0443 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0443 | 1 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0443 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0393 | 0.7743 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.022 | 0 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0443 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0443 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0443 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0443 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0223 | 0.0151 | 0.0151 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 nM | Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1 | ChEMBL. | 7490729 |
IC50 (binding) | > 1 uM | Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells | ChEMBL. | No reference |
IC50 (binding) | > 1 uM | Inhibition of binding of [125I]-SP to the CHO cell line expressing human Tachykinin receptor 1 | ChEMBL. | 7490729 |
IC50 (binding) | > 1 uM | Displacement of [125]Substance P Binding from human Neurokinin NK1 receptor in CHO Cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.