Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1977 | 0.5948 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.322 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.322 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1977 | 0.5948 | 0.5948 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0418 | 0.0871 | 0.0871 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1977 | 0.5948 | 0.5948 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.322 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0177 | 0.0084 | 0.0084 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.322 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1977 | 0.5948 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.322 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0418 | 0.0871 | 0.0871 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0177 | 0.0084 | 0.0084 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1977 | 0.5948 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.101 | 0.28 | 0.28 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0177 | 0.0084 | 0.0084 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0151 | 0 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0418 | 0.0871 | 0.0871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Effect (functional) | = 10 % | Compound is measured for oral antihypertensive activity in groups of 6-12 conscious spontaneously hypertensive rats at 250 mg/kg; Range is 10-15% | ChEMBL. | 7452693 |
Effect (functional) | = 10 % | Compound is measured for oral antihypertensive activity in groups of 6-12 deoxy-corticosterone-sodium hypertensive (DOCA-Na) rats at 10 mg/kg; Range is 10-15% | ChEMBL. | 7452693 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.