Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0235 | 0.5902 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0292 | 0.85 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0176 | 0.3184 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0324 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0107 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0107 | 0 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0324 | 1 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0292 | 0.85 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0324 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.5096 | 0.4103 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.5096 | 0.4103 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0107 | 0 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0324 | 1 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0107 | 0 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0324 | 1 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.031 | 0.9342 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0324 | 1 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0324 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0324 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0324 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0235 | 0.5902 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0292 | 0.85 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0235 | 0.5902 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0324 | 1 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0292 | 0.85 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0324 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0292 | 0.85 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.