Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0074 | 0.5 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0074 | 0.5 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0074 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.5 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0074 | 0.5 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.5 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0074 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.4 nM l-1 | Compound was tested in vitro for the inhibition of GHRH induced GH release in primary cultures of rat pituitary cells | ChEMBL. | 12773038 |
Log Ki (binding) | < 7 | Binding affinity towards human Somatostatin receptor type 4 (sst4) using Tyr11-[125I]-SRIF as radioligand was determined in CHO cells | ChEMBL. | 12773038 |
Log Ki (binding) | = 8.2 | Binding affinity towards human Somatostatin receptor type 1 (sst1) using Tyr11-[125I]-SRIF as radioligand was determined in CHO cells | ChEMBL. | 12773038 |
Log Ki (binding) | = 9 | Binding affinity towards human Somatostatin receptor type 2 (sst2) using Tyr11-[125I]-SRIF as radioligand was determined in CHO cells | ChEMBL. | 12773038 |
Log Ki (binding) | = 9.1 | Binding affinity towards human Somatostatin receptor type 3 (sst3) using Tyr11-[125I]-SRIF as radioligand was determined in CHO cells | ChEMBL. | 12773038 |
Log Ki (binding) | = 9.9 | Binding affinity towards human Somatostatin receptor type 5 (sst5) using Tyr11-[125I]-SRIF as radioligand was determined in COS cell | ChEMBL. | 12773038 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.