Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | topoisomerase I | 0.0615 | 0.3798 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.12 | 1 | 0.5 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0615 | 0.3798 | 0.5 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0461 | 0.2159 | 0.5 |
Brugia malayi | DNA topoisomerase I | 0.0615 | 0.3798 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0461 | 0.2159 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0461 | 0.2159 | 0.5 |
Onchocerca volvulus | 0.0257 | 0 | 0.5 | |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0615 | 0.3798 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1116 | 0.9104 | 0.5 |
Plasmodium vivax | topoisomerase I, putative | 0.0615 | 0.3798 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0615 | 0.3798 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0615 | 0.3798 | 0.5 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0615 | 0.3798 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKB (functional) | = 5.6 | Compound was evaluated for antagonism of contractile response of rat portal vein at Tachykinin receptor 3 | ChEMBL. | 1321907 |
pKB (functional) | = 6.6 | Compound was evaluated for antagonism of contractile response of guinea pig ileum longitudinal smooth muscle (GPI) at Tachykinin receptor 1 | ChEMBL. | 1321907 |
pKB (functional) | = 8.8 | Compound was evaluated for antagonism of contractile response of rat colon muscularis mucosae (RC) at Tachykinin receptor 2 | ChEMBL. | 1321907 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.