Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0802 | 0.0834 |
Onchocerca volvulus | 0.0139 | 0.5963 | 0.6098 | |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5963 | 0.6196 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0802 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.9624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0802 | 0.0834 |
Onchocerca volvulus | 0.0036 | 0.0802 | 0.0597 | |
Onchocerca volvulus | 0.0036 | 0.0802 | 0.0597 | |
Onchocerca volvulus | 0.0036 | 0.0802 | 0.0597 | |
Brugia malayi | Trypsin family protein | 0.0212 | 0.9624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0242 | 0.0252 |
Onchocerca volvulus | 0.0036 | 0.0802 | 0.0597 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0802 | 0.0834 |
Brugia malayi | Trypsin family protein | 0.0036 | 0.0802 | 0.0597 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0212 | 0.9624 | 0.9591 |
Onchocerca volvulus | 0.0036 | 0.0802 | 0.0597 | |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.9624 | 1 |
Onchocerca volvulus | 0.0175 | 0.7794 | 0.805 | |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0139 | 0.5963 | 0.5 |
Onchocerca volvulus | 0.0212 | 0.9624 | 1 | |
Brugia malayi | Trypsin family protein | 0.0036 | 0.0802 | 0.0597 |
Brugia malayi | Protein kinase domain containing protein | 0.0139 | 0.5963 | 0.6098 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0139 | 0.5963 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0139 | 0.5963 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.5963 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0139 | 0.5963 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.0036 | 0.0802 | 0.0834 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0802 | 0.0834 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0139 | 0.5963 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0139 | 0.5963 | 0.6196 |
Brugia malayi | Trypsin family protein | 0.0036 | 0.0802 | 0.0597 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0802 | 0.0597 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.5963 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0036 | 0.0802 | 0.0597 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0036 | 0.0802 | 0.0597 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.004 | 0.0993 | 0.0207 |
Brugia malayi | Kringle domain containing protein | 0.0139 | 0.5963 | 0.6098 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.5963 | 0.5611 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0802 | 0.0834 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MST (functional) | = -0.1 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | = -0.1 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | ND 0 day | Antimalarial effect measured in trophozoite induced P. berghei mice at dose of 320 mg/kg after sc administration. | ChEMBL. | 7009867 |
MST (functional) | 0 day | Antimalarial effect measured against trophozoite induced Plasmodium berghei in mice at dosage of 80 mg/kg after sc administration; no data | ChEMBL. | 7009867 |
MST (functional) | 0 day | Antimalarial effect measured against trophozoite induced P. berghei in mice at dosage of 20 mg/kg after sc administration; no data | ChEMBL. | 7009867 |
MST (functional) | 0 day | Antimalarial effect of the compound was measured against trophozoite induced P. berghei in mice at dosage of 160 mg/kg after sc administration; no data | ChEMBL. | 7009867 |
MST (functional) | ND 0 day | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice. | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect of the compound was measured against trophozoite induced P. berghei in mice at dosage of 160 mg/kg after sc administration; No. of mice surviving after 60 days 1 | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect measured in trophozoite induced P. berghei mice at dose of 80 mg/kg after sc administration. | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice at dosage of 20 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect of the compound was measured against trophozoite induced P. berghei in mice at dosage of 160 mg/kg after sc administration; No. of mice surviving after 60 days 1 | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect measured in trophozoite induced P. berghei mice at dose of 80 mg/kg after sc administration. | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | = 0.2 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice at dosage of 20 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 0.4 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | = 0.4 day | Antimalarial effect of the compound was measured against trophozoite induced Plasmodium berghei in mice after subcutaneous administration at 40 mg/kg | ChEMBL. | 7009867 |
MST (functional) | = 0.9 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice at dosage of 160 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 0.9 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice at dosage of 160 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 3.2 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice at dosage of 320 mg/kg after sc administration | ChEMBL. | 7009867 |
MST (functional) | = 3.2 day | Antimalarial effect against trophozoite induced Plasmodium berghei in mice at dosage of 320 mg/kg after sc administration | ChEMBL. | 7009867 |
MST (functional) | = 5.4 day | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice at dosage of 640 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 5.4 day | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice at dosage of 640 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 5.9 day | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice at dosage of 640 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 5.9 day | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice at dosage of 640 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 10.3 day | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice at dosage of 640 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
MST (functional) | = 10.3 day | Antimalarial effect against trophozoite-induced Plasmodium berghei in mice at dosage of 640 mg/kg after subcutaneous administration. | ChEMBL. | 7009867 |
ND (functional) | 0 | The ratio of SD90 of the quinine hydrocloride, to the SD90 of the test substance for the Dose of mg/kg; no data | ChEMBL. | 7009867 |
Ratio (functional) | ND 0 | The ratio of SD90 of the quinine hydrocloride, to the SD90 of the test substance for the Dose of mg/kg | ChEMBL. | 7009867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.