Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Endothelin receptor ET-A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 21.1 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | Endothelin receptor ET-A | 426 aa | 412 aa | 20.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Onchocerca volvulus | 0.0153 | 1 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1195 | 0.1195 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0153 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0071 | 0.1195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Contraction (functional) | = 7 % | Percent of endothelin-1 induced contraction of carotid arteries isolated from New Zealand white rabbits, tested at 1 microM concentration of compound | ChEMBL. | No reference |
Kd (binding) | = 188 nM | Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]-ET-1 as radioligand | ChEMBL. | No reference |
Kd (binding) | = 188 nM | Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]-ET-1 as radioligand | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.