Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | metacaspase 5, putative | 0.0555 | 0.2831 | 0.5 |
Echinococcus multilocularis | caspase 3 | 0.0651 | 0.3895 | 0.3373 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0555 | 0.2831 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0555 | 0.2831 | 0.5 |
Brugia malayi | Cell death protein 3 precursor | 0.0924 | 0.6893 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0555 | 0.2831 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0555 | 0.2831 | 0.5 |
Trypanosoma brucei | metacaspase MCA2 | 0.0555 | 0.2831 | 0.5 |
Leishmania major | metacaspase, putative | 0.0555 | 0.2831 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.0788 | 0.1143 |
Echinococcus multilocularis | caspase 2 | 0.0924 | 0.6893 | 0.6627 |
Echinococcus multilocularis | caspase | 0.1206 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Trypanosoma brucei | Metacaspase-4 | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Trypanosoma cruzi | metacaspase 5, putative | 0.0555 | 0.2831 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0924 | 0.6893 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0555 | 0.2831 | 0.5 |
Echinococcus granulosus | caspase 8 | 0.0555 | 0.2831 | 0.2218 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0555 | 0.2831 | 0.5 |
Brugia malayi | hypothetical protein | 0.0369 | 0.0788 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0555 | 0.2831 | 0.4108 |
Plasmodium falciparum | metacaspase-like protein | 0.0555 | 0.2831 | 0.5 |
Echinococcus granulosus | caspase 2 | 0.0924 | 0.6893 | 0.6627 |
Trypanosoma brucei | metacaspase | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.1206 | 1 | 1 |
Echinococcus granulosus | caspase 3 | 0.0651 | 0.3895 | 0.3373 |
Echinococcus granulosus | caspase | 0.1206 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0924 | 0.6893 | 1 |
Echinococcus multilocularis | caspase 8 | 0.0555 | 0.2831 | 0.2218 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0555 | 0.2831 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.1206 | 1 | 1 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Trypanosoma cruzi | metacaspase, putative | 0.0555 | 0.2831 | 0.5 |
Trypanosoma brucei | metacaspase 5, putative | 0.0555 | 0.2831 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.1206 | 1 | 1 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0555 | 0.2831 | 0.5 |
Plasmodium falciparum | metacaspase 1 | 0.0555 | 0.2831 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0924 | 0.6893 | 0.6627 |
Brugia malayi | mucosa associated lymphoid tissue lymphoma translocation protein 1 | 0.0555 | 0.2831 | 0.4108 |
Trichomonas vaginalis | Clan CD, family C14, metacaspase-like cysteine peptidase | 0.0555 | 0.2831 | 0.5 |
Toxoplasma gondii | ICE family protease (caspase) p20 domain-containing protein | 0.0555 | 0.2831 | 0.5 |
Trypanosoma brucei | metacaspase MCA3 | 0.0555 | 0.2831 | 0.5 |
Plasmodium vivax | metacaspase 1, putative | 0.0555 | 0.2831 | 0.5 |
Schistosoma mansoni | subfamily C14A unassigned peptidase (C14 family) | 0.0555 | 0.2831 | 0.2218 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 140 nM | Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]-bradykinin displacement. | ChEMBL. | 10514289 |
Ki (binding) | = 160 nM | Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]-bradykinin displacement. | ChEMBL. | 10514289 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.