Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.4677 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.0844 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.0844 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0044 | 0.0844 | 0.1804 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Giardia lamblia | Cathepsin B precursor | 0.0044 | 0.0844 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0044 | 0.0844 | 0.1804 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0133 | 0.4677 | 1 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Echinococcus multilocularis | cathepsin b | 0.0133 | 0.4677 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0044 | 0.0844 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Echinococcus granulosus | cathepsin b | 0.0133 | 0.4677 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 0.4677 | 1 |
Echinococcus granulosus | cathepsin b | 0.0133 | 0.4677 | 1 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0133 | 0.4677 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0044 | 0.0844 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0133 | 0.4677 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 0.4677 | 1 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0044 | 0.0844 | 0.5 |
Onchocerca volvulus | 0.0024 | 0 | 0.5 | |
Echinococcus multilocularis | cathepsin b | 0.0133 | 0.4677 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0133 | 0.4677 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 520 nM | Inhibition of 1,3-beta-D-glucan synthase (GS) from candida albicans | ChEMBL. | 11212119 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.