Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.084 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0125 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.084 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.01 uM | Inhibition of CD28-CD80 interaction in the absence of fetal bovine serum (FBS) | ChEMBL. | 12565974 |
IC50 (binding) | = 0.13 uM | Inhibitory concentration of the compound against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uM | ChEMBL. | 12565974 |
IC50 (binding) | = 0.38 uM | Inhibition of CD28-CD80 interaction in the presence of fetal bovine serum (FBS) | ChEMBL. | 12565974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.