Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0299 | 0.4553 |
Loa Loa (eye worm) | glutaminase 2 | 0.0308 | 0.0625 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0351 | 0.5623 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.0299 | 0.0412 |
Loa Loa (eye worm) | glutaminase | 0.0308 | 0.0625 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.0351 | 0.5623 |
Echinococcus multilocularis | geminin | 0.0191 | 0.0351 | 0.1722 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0037 | 0.0181 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0026 | 0.0411 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1179 | 0.2663 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0026 | 0.0126 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0026 | 0.0411 |
Schistosoma mansoni | glutaminase | 0.0308 | 0.0625 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0037 | 0.0181 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0026 | 0.0411 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0026 | 0.0126 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1179 | 0.2663 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.3136 | 0.7243 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0308 | 0.0625 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0026 | 0.0732 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1179 | 0.2663 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1179 | 0.2663 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.0299 | 0.8496 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0299 | 0.4553 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0037 | 0.005 |
Trichomonas vaginalis | glutaminase, putative | 0.0308 | 0.0625 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.0299 | 0.1463 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0037 | 0.005 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0026 | 0.0035 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0308 | 0.0625 | 0.0863 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.0299 | 0.1463 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0026 | 0.0732 |
Echinococcus granulosus | geminin | 0.0191 | 0.0351 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0913 | 0.204 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.1179 | 0.2663 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1179 | 0.2663 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1179 | 0.2663 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1179 | 0.2663 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Dose (functional) | 0 mg kg-1 | Minimal dose necessary to eliminate > 83% of Trichostrongylus colubriformis infection in gerbils; No data | ChEMBL. | 7097720 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.