Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0051 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0032 | 0.2407 | 0.2407 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0051 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0051 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0051 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0051 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0051 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0051 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0051 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0051 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0051 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0051 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0026 | 0.0151 | 0.0151 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0025 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0051 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0051 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0045 | 0.7743 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0032 | 0.2407 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0051 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0051 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0051 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0051 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0045 | 0.7743 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0051 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0051 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0051 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9.08 | Inhibition of the in vitro binding of [125I]-labeled leuprolide to the rat pituitary luteinizing hormone releasing hormone (LHRH) receptor. | ChEMBL. | 7510341 |
Log Ki (binding) | = 9.08 | Inhibition of the in vitro binding of [125I]-labeled leuprolide to the rat pituitary luteinizing hormone releasing hormone (LHRH) receptor. | ChEMBL. | 7510341 |
pA2 (functional) | = 7.67 | In vitro antagonistic potency against release of luteinizing hormone (LH) from cultured rat pituitary cells. | ChEMBL. | 7510341 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.