Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0365 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0365 | 0.5 | 0.5 | |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0365 | 0.5 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0365 | 0.5 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0365 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | 0 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pyogenes ATCC 19615 was determined; NT=not tested | ChEMBL. | 15713376 |
MIC (functional) | <= 0.125 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pyogenes 3029 was determined | ChEMBL. | 15713376 |
MIC (functional) | <= 0.125 ug ml-1 | Minimum inhibitory concentration of compound against Ery-S S. pneumoniae ATCC 49619 was determined | ChEMBL. | 15713376 |
MIC (functional) | <= 0.125 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pneumoniae 163 was determined | ChEMBL. | 15713376 |
MIC (functional) | <= 0.125 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pneumoniae 303 was determined | ChEMBL. | 15713376 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pneumoniae 5032 was determined | ChEMBL. | 15713376 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pyogenes 1850 was determined | ChEMBL. | 15713376 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pyogenes 3262 was determined | ChEMBL. | 15713376 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration of compound against Ery-S H. influenzae ATCC 49247 was determined | ChEMBL. | 15713376 |
MIC (functional) | = 4 ug ml-1 | Minimum inhibitory concentration of compound against Ery-S S. pneumoniae 3773 was determined | ChEMBL. | 15713376 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration of compound against Ery-R S. pyogenes 1721 was determined | ChEMBL. | 15713376 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.