Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0146 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0136 | 0.8408 | 0.5 |
Echinococcus granulosus | cathepsin b | 0.0136 | 0.8408 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0136 | 0.8408 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0136 | 0.8408 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0146 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0146 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0136 | 0.8408 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Diet (functional) | ND 0 % | In vivo Sterol lowering activity at dose as 0.03 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Sterol lowering activity at dose as 0.01 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Triglyceride lowering activity at dose as 0.03 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | ND 0 % | In vivo Triglyceride lowering activity at dose as 0.01 % of the diet;ND means no data. | ChEMBL. | 6604816 |
Diet (functional) | = 82 % | In vivo triglyceride lowering activity, dosed at 0.10 % of the diet. | ChEMBL. | 6604816 |
Diet (functional) | = 106 % | In vivo Sterol lowering activity at dose as 0.10 % of the diet. | ChEMBL. | 6604816 |
Inhibition (binding) | = 21 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Inhibition (binding) | = 21 % | In vitro inhibitory activity against acyl coenzyme A:cholesterol acyltransferase (ACAT) | ChEMBL. | 6604816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.