Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.018 | 0.1972 | 0.1972 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0682 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0467 | 0.6554 | 0.6554 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0149 | 0.1462 | 0.1462 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0467 | 0.6554 | 0.6554 |
Loa Loa (eye worm) | SRC-1 | 0.018 | 0.1972 | 0.0909 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0467 | 0.6554 | 0.6554 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6554 | 0.6097 |
Entamoeba histolytica | protein kinase, putative | 0.013 | 0.1169 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.3172 | 0.2268 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0467 | 0.6554 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus granulosus | enteropeptidase | 0.0467 | 0.6554 | 0.6554 |
Onchocerca volvulus | 0.0467 | 0.6554 | 0.5 | |
Onchocerca volvulus | 0.0467 | 0.6554 | 0.5 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0306 | 0.3975 | 0.482 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.018 | 0.1972 | 0.1972 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0156 | 0.1576 | 0.1576 |
Loa Loa (eye worm) | TK protein kinase | 0.0156 | 0.1576 | 0.046 |
Loa Loa (eye worm) | trypsin family protein | 0.0467 | 0.6554 | 0.6097 |
Echinococcus multilocularis | enteropeptidase | 0.0467 | 0.6554 | 0.6554 |
Onchocerca volvulus | 0.0467 | 0.6554 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6554 | 0.6097 |
Onchocerca volvulus | 0.0467 | 0.6554 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6554 | 0.6097 |
Schistosoma mansoni | tyrosine kinase | 0.0657 | 0.9594 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0156 | 0.1576 | 0.1576 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0149 | 0.1462 | 0.1462 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.1972 | 0.2055 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Brugia malayi | Trypsin family protein | 0.0467 | 0.6554 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0467 | 0.6554 | 0.6831 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus granulosus | tyrosine kinase | 0.0156 | 0.1576 | 0.1576 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6554 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0682 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.018 | 0.1972 | 0.1972 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.013 | 0.1169 | 0.1169 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0467 | 0.6554 | 0.6554 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6554 | 0.6097 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.018 | 0.1972 | 0.1972 |
Brugia malayi | Trypsin family protein | 0.0467 | 0.6554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6554 | 0.6097 |
Onchocerca volvulus | 0.0467 | 0.6554 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0156 | 0.1576 | 0.1576 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0156 | 0.1576 | 0.1576 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0401 | 0.5505 | 0.7893 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Brugia malayi | Trypsin family protein | 0.0467 | 0.6554 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0467 | 0.6554 | 0.6554 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.018 | 0.1972 | 0.1972 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0306 | 0.3975 | 0.3975 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Brugia malayi | Trypsin family protein | 0.0467 | 0.6554 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.1972 | 0.2055 |
Echinococcus granulosus | Mastin | 0.0467 | 0.6554 | 0.6554 |
Mycobacterium ulcerans | hypothetical protein | 0.0467 | 0.6554 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0156 | 0.1576 | 0.1576 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.018 | 0.1972 | 0.1972 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Brugia malayi | hypothetical protein | 0.0467 | 0.6554 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.013 | 0.1169 | 0.1169 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0467 | 0.6554 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0467 | 0.6554 | 0.6554 |
Onchocerca volvulus | 0.0467 | 0.6554 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.018 | 0.1972 | 0.1972 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6554 | 0.6097 |
Loa Loa (eye worm) | hypothetical protein | 0.0467 | 0.6554 | 0.6097 |
Brugia malayi | SRC-1 | 0.018 | 0.1972 | 0.0796 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.018 | 0.1972 | 0.1972 |
Schistosoma mansoni | hypothetical protein | 0.0467 | 0.6554 | 0.6831 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.018 | 0.1972 | 0.1972 |
Echinococcus multilocularis | Mastin | 0.0467 | 0.6554 | 0.6554 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0467 | 0.6554 | 0.6554 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.018 | 0.1972 | 0.1972 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0467 | 0.6554 | 0.6831 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.81 nM | Relative effective concentration against human somatostatin receptor type 2 expressed in CHO cells; (n=3) | ChEMBL. | 15828816 |
ID/g (functional) | = 25.1 % | In vivo tumor accumulation was determined in nude mice bearing rat pancreatic AR42J tumor cell expressed with somatostatin receptor type 2;60 min p.i.; (n=3-5) | ChEMBL. | 15828816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.