Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.1397 | 0.5241 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0751 | 0.1737 | 0.32 |
Treponema pallidum | DNA polymerase III subunit alpha | 0.2275 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0743 | 0.1694 | 0.3117 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0751 | 0.1737 | 0.3299 |
Schistosoma mansoni | tyrosine kinase | 0.0751 | 0.1737 | 0.32 |
Mycobacterium ulcerans | error-prone DNA polymerase | 0.2275 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0446 | 0.0087 | 0.0145 |
Schistosoma mansoni | tyrosine kinase | 0.0743 | 0.1694 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0751 | 0.1737 | 0.32 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1397 | 0.5241 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0751 | 0.1737 | 0.32 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1397 | 0.5241 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) | 0.2275 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1397 | 0.5241 | 1 |
Mycobacterium ulcerans | DNA polymerase III subunit alpha | 0.2275 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1397 | 0.5241 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0743 | 0.1694 | 0.3117 |
Mycobacterium tuberculosis | Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) | 0.2275 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA polymerase III alpha subunit | 0.2275 | 1 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0446 | 0.0087 | 0.0145 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) | 0.2275 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 26 % | Inhibition of T6-17 cell proliferation | ChEMBL. | 11472210 |
Kd (binding) | = 0.35 uM | Dissociation constant for peptide inhibtor binding to HER2 receptor | ChEMBL. | 11472210 |
Kd (binding) | = 0.35 uM | Dissociation constant for peptide inhibtor binding to HER2 receptor | ChEMBL. | 11472210 |
Koff (binding) | = 0.000603 s-1 | Kinetic constant for peptide inhibitor binding to HER2 receptor | ChEMBL. | 11472210 |
Kon (binding) | = 1720 M-1 s-1 | Kinetic constant for peptide inhibitor binding to HER2 receptor | ChEMBL. | 11472210 |
k_off (binding) | = 0.000603 s-1 | Kinetic constant for peptide inhibitor binding to HER2 receptor | ChEMBL. | 11472210 |
k_on (binding) | = 1720 M-1 s-1 | Kinetic constant for peptide inhibitor binding to HER2 receptor | ChEMBL. | 11472210 |
S | 0 | Solubility of the compound in the PBS buffer at 1 mg/mL; Good solubility | ChEMBL. | 11472210 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.