Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0084 | 0.0074 | 0.0086 |
Echinococcus multilocularis | kinesin family 1 | 0.2354 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0123 | 0.0244 | 0.0171 |
Echinococcus granulosus | voltage gated potassium channel | 0.0123 | 0.0244 | 0.0171 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0123 | 0.0244 | 0.0171 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0462 | 0.1729 | 0.1996 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0244 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0423 | 0.1559 | 0.1496 |
Brugia malayi | Kinesin motor domain containing protein | 0.0306 | 0.1045 | 0.6537 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0123 | 0.0244 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0368 | 0.1315 | 0.8354 |
Giardia lamblia | Kinesin-5 | 0.0306 | 0.1045 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0396 | 0.1438 | 1 |
Plasmodium falciparum | kinesin-5 | 0.0306 | 0.1045 | 0.5 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0084 | 0.0074 | 0.0086 |
Schistosoma mansoni | kinesin eg-5 | 0.0306 | 0.1045 | 0.1206 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0462 | 0.1729 | 0.1996 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0423 | 0.1559 | 0.1496 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0423 | 0.1559 | 1 |
Schistosoma mansoni | hypothetical protein | 0.2048 | 0.8663 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0306 | 0.1045 | 0.6537 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0084 | 0.0074 | 0.0086 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0123 | 0.0244 | 0.0282 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0423 | 0.1559 | 1 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0084 | 0.0074 | 0.0086 |
Plasmodium vivax | kinesin-5 | 0.0306 | 0.1045 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0306 | 0.1045 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0123 | 0.0244 | 0.1145 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0084 | 0.0074 | 0.0086 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0396 | 0.1438 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0306 | 0.1045 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0123 | 0.0244 | 0.0171 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0074 | 0.0086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 84 % | Displacement of [3H]-DHT (4 nM) binding to human androgen receptor (hAR) at 10 uM | ChEMBL. | 15582444 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.