Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0107 | 0.2796 | 0.5 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.0107 | 0.2796 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0107 | 0.2796 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0107 | 0.2796 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0107 | 0.2796 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0135 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0107 | 0.2796 | 0.2796 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0107 | 0.2796 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0107 | 0.2796 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 1 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0135 | 1 | 1 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0107 | 0.2796 | 0.5 |
Echinococcus multilocularis | lysosomal protective protein | 0.0107 | 0.2796 | 0.2796 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0107 | 0.2796 | 0.5 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0107 | 0.2796 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP (functional) | = 174 mmHg | Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 100 mg/kg,po after 24 hours of postdose-1. | ChEMBL. | 7452694 |
BP (functional) | = 181 mmHg | Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 100 mg/kg,po after 24 hours of postdose-2 | ChEMBL. | 7452694 |
BP (functional) | = 188 mmHg | Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 100 mg/kg,po after 4 hours of postdose-2 | ChEMBL. | 7452694 |
BP (functional) | = 192 mmHg | Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 100 mg/kg,po after 4 hours of postdose-1. | ChEMBL. | 7452694 |
BP (functional) | = 196 mmHg | Antihypertensive activity in spontaneously hypertensive rats was measured as average blood pressure at 100 mg/kg,po before predose | ChEMBL. | 7452694 |
Heart rate (functional) | = 0 | Antihypertensive activity in spontaneously hypertensive rats was measured as change in heart rate at 100 mg/kg peroral dose; 0=No significant change in heart rate | ChEMBL. | 7452694 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.