Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0119 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0119 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0119 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0119 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0119 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0119 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0119 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0119 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0119 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0119 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0119 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Activity at human adenosine A3 receptor in CHO cells assessed as inhibition of forskolin-stimulated cAMP production relative to NECA at 10 uM | ChEMBL. | 17149867 |
Activity (binding) | < 50 % | Activity at human adenosine A2A receptor in CHO cells assessed as stimulation of cAMP production relative to NECA at 10 uM | ChEMBL. | 17149867 |
Activity (binding) | < 50 % | Activity at human adenosine A2A receptor in CHO cells assessed as stimulation of cAMP production relative to NECA at 10 uM | ChEMBL. | 17149867 |
Efficacy (functional) | = 90 % | Activity at human adenosine A3 receptor in CHO cells assessed as inhibition of forskolin-stimulated cAMP production relative to NECA at 10 uM | ChEMBL. | 17149867 |
Efficacy (functional) | = 90 % | Activity at human adenosine A3 receptor in CHO cells assessed as inhibition of forskolin-stimulated cAMP production relative to NECA at 10 uM | ChEMBL. | 17149867 |
Inhibition (binding) | = 45 % | Inhibition of [3H]CGS21680 binding to human Adenosine A2A receptor expressed in CHO cells at 10 uM | ChEMBL. | 17149867 |
Inhibition (binding) | = 45 % | Inhibition of [3H]CGS21680 binding to human Adenosine A2A receptor expressed in CHO cells at 10 uM | ChEMBL. | 17149867 |
Ki (binding) | = 1.8 nM | Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 17149867 |
Ki (binding) | = 1.8 nM | Displacement of [125I]AB-MECA from human Adenosine A3 receptor expressed in CHO cells | ChEMBL. | 17149867 |
Ki (binding) | = 1640 nM | Displacement of [3H]CCPA from human Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 17149867 |
Ki (binding) | = 1640 nM | Displacement of [3H]CCPA from human Adenosine A1 receptor expressed in CHO cells | ChEMBL. | 17149867 |
Selectivity ratio (binding) | = 910 | Selectivity for human adenosine A3 over human adenosine A1 receptor | ChEMBL. | 17149867 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.