Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0705 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0705 | 0.5 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0705 | 0.5 | 0.5 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0705 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0705 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0705 | 0.5 | 0.5 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0705 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0705 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0705 | 0.5 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0705 | 0.5 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0705 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0705 | 0.5 | 0.5 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0705 | 0.5 | 0.5 |
Plasmodium vivax | RNA helicase-1, putative | 0.0705 | 0.5 | 0.5 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0705 | 0.5 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0705 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0705 | 0.5 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0705 | 0.5 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0705 | 0.5 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0705 | 0.5 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0705 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0705 | 0.5 | 0.5 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0705 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 16 % | Calcemic activity in Sprague-Dawley rat measured as urinary calcium excretion relative to calcitriol | ChEMBL. | 17149880 |
ED50 (binding) | = 0.6 nM | Activity on human VDR-mediated transcription of osteocalcin VDRE fused to thymidine kinase promoter/growth hormone reporter gene in CV1 cells | ChEMBL. | 17149880 |
ED50 (binding) | = 0.6 nM | Activity on human VDR-mediated transcription of osteocalcin VDRE fused to thymidine kinase promoter/growth hormone reporter gene in CV1 cells | ChEMBL. | 17149880 |
ED50 (functional) | = 2 nM | Antiproliferative activity against murine keratinocytes | ChEMBL. | 17149880 |
ED50 (binding) | = 4 nM | Stabilization of human [35S]VDR against trypsin digestion by protease assay | ChEMBL. | 17149880 |
ED50 (binding) | = 4 nM | Stabilization of human [35S]VDR against trypsin digestion by protease assay | ChEMBL. | 17149880 |
IC50 (binding) | = 50 nM | Displacement of [3H]1,25-dihydroxyvitamin D3 from human VDR by HAP assay | ChEMBL. | 17149880 |
IC50 (binding) | = 50 nM | Displacement of [3H]1,25-dihydroxyvitamin D3 from human VDR by HAP assay | ChEMBL. | 17149880 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.