Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Rattus norvegicus | Cannabinoid CB1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | kinesin-5 | 0.0196 | 0.1018 | 0.5 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0059 | 0.0082 | 0.0095 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.027 | 0.0312 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0298 | 0.1723 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0196 | 0.1018 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0086 | 0.027 | 0.1145 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0059 | 0.0082 | 0.0095 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0196 | 0.1018 | 0.5704 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0086 | 0.027 | 0.019 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0059 | 0.0082 | 0.0095 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0059 | 0.0082 | 0.0095 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0279 | 0.1589 | 1 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0196 | 0.1018 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0298 | 0.1723 | 0.1655 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0086 | 0.027 | 0.0312 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.1453 | 0.8354 |
Brugia malayi | Kinesin motor domain containing protein | 0.0196 | 0.1018 | 0.5704 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0059 | 0.0082 | 0.0095 |
Echinococcus multilocularis | kinesin family 1 | 0.1505 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0326 | 0.1911 | 0.2207 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.027 | 0.1145 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0086 | 0.027 | 0.019 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0086 | 0.027 | 0.019 |
Echinococcus granulosus | voltage gated potassium channel | 0.0086 | 0.027 | 0.019 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0298 | 0.1723 | 1 |
Schistosoma mansoni | hypothetical protein | 0.131 | 0.8659 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0298 | 0.1723 | 0.1655 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0326 | 0.1911 | 0.2207 |
Giardia lamblia | Kinesin-5 | 0.0196 | 0.1018 | 0.5 |
Plasmodium falciparum | kinesin-5 | 0.0196 | 0.1018 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0279 | 0.1589 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0196 | 0.1018 | 0.1176 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0059 | 0.0082 | 0.0095 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 41 nM | Displacement of [3H]CP 55940 from human cloned CB2 receptor | ChEMBL. | 16889960 |
Ki (binding) | = 41 nM | Displacement of [3H]CP 55940 from human cloned CB2 receptor | ChEMBL. | 16889960 |
Ki (binding) | = 100 nM | Displacement of [3H]CP 55940 from CB1 receptor in rat brain | ChEMBL. | 16889960 |
Ki (binding) | = 100 nM | Displacement of [3H]CP 55940 from CB1 receptor in rat brain | ChEMBL. | 16889960 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.