Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0656 | 0.7464 | 0.8082 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0656 | 0.7464 | 0.5 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0656 | 0.7464 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0656 | 0.7464 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0656 | 0.7464 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0656 | 0.7464 | 0.7464 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0656 | 0.7464 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.075 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0656 | 0.7464 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0656 | 0.7464 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0722 | 0.9236 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.6 ug ml-1 | In vitro antibacterial activity against Streptococcus pyogenes | ChEMBL. | 7310826 |
MIC (functional) | = 6.2 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus | ChEMBL. | 7310826 |
MIC (functional) | = 12.5 ug ml-1 | In vitro antifungal activity against Aspergillus fumigatus | ChEMBL. | 7310826 |
MIC (functional) | = 25 ug ml-1 | In vitro antifungal activity against Candida albicans | ChEMBL. | 7310826 |
MIC (functional) | = 50 ug ml-1 | In vitro antifungal activity against Trichophyton asteroides | ChEMBL. | 7310826 |
MIC (functional) | > 100 ug ml-1 | In vitro antibacterial activity tested against Escherichia coli | ChEMBL. | 7310826 |
MIC (functional) | > 100 ug ml-1 | In vitro antibacterial activity tested against Klebsiella pneumoniae | ChEMBL. | 7310826 |
MIC (functional) | > 100 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa | ChEMBL. | 7310826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.