Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.005 | 0.0217 | 0.0217 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0654 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1452 | 0.1452 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.005 | 0.0217 | 0.0217 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0126 | 0.1452 | 0.1452 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0654 | 1 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0654 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0654 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0126 | 0.1452 | 0.1452 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0654 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0126 | 0.1452 | 0.1452 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0126 | 0.1452 | 0.1452 |
Loa Loa (eye worm) | hypothetical protein | 0.0654 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0654 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0126 | 0.1452 | 0.1452 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0113 | 0.1237 | 0.1043 |
Plasmodium vivax | RNA helicase-1, putative | 0.0654 | 1 | 1 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0654 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0654 | 1 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0654 | 1 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0654 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0654 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0654 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0126 | 0.1452 | 0.1452 |
Trypanosoma cruzi | oligopeptidase b | 0.005 | 0.0217 | 0.0217 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0654 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.005 | 0.0217 | 0.0217 |
Leishmania major | oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein | 0.005 | 0.0217 | 0.0217 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0654 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0654 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.005 | 0.0217 | 0.5 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0654 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0654 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.005 | 0.0217 | 0.5 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0654 | 1 | 1 |
Toxoplasma gondii | prolyl endopeptidase | 0.0126 | 0.1452 | 0.1452 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0654 | 1 | 1 |
Trypanosoma brucei | oligopeptidase b | 0.005 | 0.0217 | 0.0217 |
Leishmania major | oligopeptidase b | 0.005 | 0.0217 | 0.0217 |
Echinococcus granulosus | prolyl endopeptidase | 0.0126 | 0.1452 | 0.1452 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0654 | 1 | 1 |
Trypanosoma cruzi | oligopeptidase b | 0.005 | 0.0217 | 0.0217 |
Trypanosoma brucei | prolyl endopeptidase | 0.0126 | 0.1452 | 0.1452 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0654 | 1 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.005 | 0.0217 | 0.0217 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Effect on gamma irradiation-induced TBARS formation in liposomes at 50 uM | ChEMBL. | 16919452 |
Activity (functional) | 0 | Antioxidant actvity assessed by singlet oxygen quenching ability | ChEMBL. | 16919452 |
IC50 (functional) | = 75 uM | Inhibition of gamma radiation-induced lipid peroxidation in liposomes | ChEMBL. | 16919452 |
IC50 (binding) | > 100 uM | Inhibition of horseradish peroxidase by spectrophotometric method | ChEMBL. | 16919452 |
Inhibition (binding) | = 33.1 % | Inhibition of horseradish peroxidase at 100 uM | ChEMBL. | 16919452 |
Km (functional) | = 2.2 mM | Glutathione peroxidase activity assessed by GSH-GSSG coupled assay | ChEMBL. | 16919452 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.