Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | histamine h1 receptor | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0043 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0043 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0043 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0043 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Brugia malayi | RE15519p | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.1531 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.1531 | 1 | 1 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0432 | 0.2616 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | myosin xvIII | 0.0043 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0043 | 0 | 0.5 |
Echinococcus multilocularis | thymidine phosphorylase | 0.1531 | 1 | 1 |
Brugia malayi | Dopamine receptor | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 33.4 uM | Inhibition of human thymidine phosphorylase by continuous spectrophotometric assay | ChEMBL. | 17181163 |
Ki (binding) | = 33.4 uM | Inhibition of human thymidine phosphorylase by continuous spectrophotometric assay | ChEMBL. | 17181163 |
Stabilty | 0 | Stability in acidic buffer at pH 1.0 in 37 degC | ChEMBL. | 17181163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.