Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Tolloid protein 1 | 0.0208 | 0.212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.212 | 0.2691 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0208 | 0.212 | 0.2691 |
Brugia malayi | Trypsin family protein | 0.0327 | 0.788 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0208 | 0.212 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.788 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0208 | 0.212 | 0.212 |
Loa Loa (eye worm) | hypothetical protein | 0.0327 | 0.788 | 1 |
Onchocerca volvulus | 0.0266 | 0.4943 | 0.6273 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.723 | 0.9175 |
Onchocerca volvulus | 0.0327 | 0.788 | 1 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0327 | 0.788 | 0.788 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (ADMET) | = 29.5 uM | Cytotoxicity against human HOP62 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 29.5 uM | Cytotoxicity against human HOP62 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 31.6 uM | Cytotoxicity against human HCT116 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 31.6 uM | Cytotoxicity against human HCT116 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 36.3 uM | Cytotoxicity against human SF539 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 36.3 uM | Cytotoxicity against human SF539 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 46.8 uM | Cytotoxicity against human SN12C cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 46.8 uM | Cytotoxicity against human SN12C cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 51.3 uM | Cytotoxicity against human UACC62 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 51.3 uM | Cytotoxicity against human UACC62 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 87.1 uM | Cytotoxicity against human DU145 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | = 87.1 uM | Cytotoxicity against human DU145 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | > 100 uM | Cytotoxicity against human OVCAR3 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | > 100 uM | Cytotoxicity against human MDA-MB-435 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | > 100 uM | Cytotoxicity against human OVCAR3 cell line | ChEMBL. | 17181156 |
GI50 (ADMET) | > 100 uM | Cytotoxicity against human MDA-MB-435 cell line | ChEMBL. | 17181156 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.