Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0083 | 0.0482 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0254 | 0.093 | 0.5402 |
Echinococcus multilocularis | kinesin family 1 | 0.1957 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0117 | 0.0197 | 0.0197 |
Echinococcus granulosus | voltage gated potassium channel | 0.0117 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0197 | 0.1145 |
Schistosoma mansoni | voltage-gated potassium channel | 0.044 | 0.1918 | 0.2219 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0117 | 0.0197 | 0.0228 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0117 | 0.0197 | 0.0228 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0403 | 0.1721 | 1 |
Schistosoma mansoni | kinesin eg-5 | 0.0254 | 0.093 | 0.1075 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0403 | 0.1721 | 0.1721 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0254 | 0.093 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0254 | 0.093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.1438 | 0.8354 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0117 | 0.0197 | 0.1145 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0117 | 0.0197 | 0.0197 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0376 | 0.158 | 1 |
Giardia lamblia | Kinesin-5 | 0.0254 | 0.093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0083 | 0.0482 |
Plasmodium falciparum | kinesin-5 | 0.0254 | 0.093 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0376 | 0.158 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0095 | 0.0083 | 0.0482 |
Brugia malayi | Kinesin motor domain containing protein | 0.0254 | 0.093 | 0.5402 |
Plasmodium vivax | kinesin-5 | 0.0254 | 0.093 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0403 | 0.1721 | 0.1721 |
Schistosoma mansoni | voltage-gated potassium channel | 0.044 | 0.1918 | 0.2219 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0403 | 0.1721 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1703 | 0.8646 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0117 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0083 | 0.0482 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 114 uM | Inhibition of [3H]methyl dThd phosphorylation by TK2 | ChEMBL. | 17181158 |
IC50 (binding) | = 114 uM | Inhibition of [3H]methyl dThd phosphorylation by TK2 | ChEMBL. | 17181158 |
IC50 (binding) | = 144 uM | Inhibition of [3H]methyl dThd phosphorylation by Drosophila melanogaster dNK | ChEMBL. | 17181158 |
IC50 (binding) | = 144 uM | Inhibition of [3H]methyl dThd phosphorylation by Drosophila melanogaster dNK | ChEMBL. | 17181158 |
IC50 (binding) | > 500 uM | Inhibition of [3H]methyl dThd phosphorylation by HSV1 TK | ChEMBL. | 17181158 |
IC50 (binding) | > 500 uM | Inhibition of [3H]methyl dThd phosphorylation by HSV1 TK | ChEMBL. | 17181158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.