Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0098 | 0.0093 | 0.0309 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.2826 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0236 | 0.1142 | 0.2063 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Onchocerca volvulus | 0.0349 | 0.201 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.201 | 0.5657 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1608 | 0.4519 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.1077 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0341 | 0.1946 | 0.7447 |
Onchocerca volvulus | Putative nachr subunit | 0.0236 | 0.1142 | 0.5653 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0165 | 0.0602 | 0.059 |
Echinococcus multilocularis | fibrillin 1 | 0.0282 | 0.1499 | 0.2717 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0341 | 0.1946 | 0.1936 |
Brugia malayi | Sushi domain | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | Fibulin-1 precursor | 0.0282 | 0.1499 | 0.1488 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.2099 | 0.5909 |
Plasmodium vivax | apical sushi protein, putative | 0.019 | 0.0791 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.1499 | 0.4211 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0098 | 0.0093 | 0.008 |
Onchocerca volvulus | Arrow homolog | 0.0282 | 0.1499 | 0.7444 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0165 | 0.0602 | 0.059 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Brugia malayi | Cation transporter family protein | 0.0236 | 0.1142 | 0.113 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.036 | 0.2093 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0236 | 0.1142 | 0.5412 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.1499 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0236 | 0.1142 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.1077 |
Echinococcus multilocularis | nAChR subunit | 0.0098 | 0.0093 | 0.0147 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.2093 | 0.5892 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.0073 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0098 | 0.0093 | 0.0227 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0361 | 0.2099 | 0.8034 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0282 | 0.1499 | 0.4211 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.3198 |
Loa Loa (eye worm) | ACC-1 protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0165 | 0.0602 | 0.2826 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Schistosoma mansoni | egf-like domain protein | 0.0282 | 0.1499 | 0.5726 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.1077 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0805 | 0.5484 | 1 |
Echinococcus multilocularis | c4b binding protein beta chain | 0.019 | 0.0791 | 0.1422 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Echinococcus granulosus | nAChR subunit | 0.0165 | 0.0602 | 0.2826 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | Tolloid protein 1 | 0.0361 | 0.2099 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1608 | 0.4519 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0098 | 0.0093 | 0.008 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Echinococcus granulosus | C type lectin domian containing protein | 0.019 | 0.0791 | 0.3731 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0089 | 0.0025 | 0.0012 |
Echinococcus granulosus | nAChR subunit | 0.0098 | 0.0093 | 0.0385 |
Leishmania major | C-8 sterol isomerase-like protein | 0.036 | 0.2093 | 1 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.1499 | 0.1488 |
Brugia malayi | Trypsin family protein | 0.0349 | 0.201 | 0.1999 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.0073 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0165 | 0.0602 | 0.167 |
Echinococcus multilocularis | serotonin receptor | 0.0297 | 0.1608 | 0.2915 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.201 | 0.5657 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0025 | 0.0033 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.0073 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0165 | 0.0602 | 0.059 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0098 | 0.0093 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Echinococcus granulosus | laminin | 0.0282 | 0.1499 | 0.7127 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0098 | 0.0093 | 0.008 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0165 | 0.0602 | 0.227 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0098 | 0.0093 | 0.0309 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0236 | 0.1142 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.019 | 0.0791 | 0.2997 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0161 | 0.0577 | 0.2172 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0236 | 0.1142 | 0.4348 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Entamoeba histolytica | hypothetical protein | 0.0098 | 0.0093 | 0.5 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | c4b binding protein beta chain | 0.019 | 0.0791 | 0.3731 |
Plasmodium falciparum | apical sushi protein | 0.019 | 0.0791 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0098 | 0.0093 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1946 | 0.5477 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus multilocularis | nAChR subunit | 0.0165 | 0.0602 | 0.1077 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.2826 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0165 | 0.0602 | 0.1077 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.019 | 0.0791 | 0.1422 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | Cation transporter family protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.019 | 0.0791 | 0.5235 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0165 | 0.0602 | 0.1077 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Onchocerca volvulus | 0.0267 | 0.1379 | 0.6842 | |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0165 | 0.0602 | 0.167 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.1499 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0633 | 0.1755 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.036 | 0.2093 | 0.2082 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0297 | 0.1608 | 0.7647 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.019 | 0.0791 | 0.5235 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.5412 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0297 | 0.1608 | 0.6144 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0361 | 0.2099 | 0.5909 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0165 | 0.0602 | 0.059 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Onchocerca volvulus | Putative cubilin | 0.0089 | 0.0025 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0349 | 0.201 | 0.7691 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Onchocerca volvulus | 0.0098 | 0.0093 | 0.0402 | |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.087 | 0.2426 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0361 | 0.2099 | 0.3812 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.075 | 0.2089 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1946 | 0.5477 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0165 | 0.0602 | 0.1077 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | LGC-31 protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Brugia malayi | GCC2 and GCC3 family protein | 0.02 | 0.087 | 0.0858 |
Echinococcus multilocularis | serotonin receptor | 0.0297 | 0.1608 | 0.2915 |
Onchocerca volvulus | 0.0098 | 0.0093 | 0.0402 | |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0165 | 0.0602 | 0.2826 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0236 | 0.1142 | 0.4348 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.1499 | 0.1488 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.1665 | 0.4679 |
Brugia malayi | Cation transporter family protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0236 | 0.1142 | 0.5412 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Echinococcus multilocularis | laminin | 0.0282 | 0.1499 | 0.2717 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.036 | 0.2093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0428 | 0.2609 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.3543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli W3110 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli W3110 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate | ChEMBL. | 17149863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.