Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cation transporter family protein | 0.0236 | 0.1142 | 0.113 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | Arrow homolog | 0.0282 | 0.1499 | 0.7444 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0165 | 0.0602 | 0.059 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0161 | 0.0577 | 0.2172 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0349 | 0.201 | 0.7691 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Echinococcus multilocularis | C type lectin domian containing protein | 0.019 | 0.0791 | 0.1422 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0282 | 0.1499 | 0.4211 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0098 | 0.0093 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0236 | 0.1142 | 0.5412 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0098 | 0.0093 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.201 | 0.5657 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0098 | 0.0093 | 0.008 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0282 | 0.1499 | 0.1488 |
Echinococcus multilocularis | fibrillin 1 | 0.0282 | 0.1499 | 0.2717 |
Plasmodium falciparum | apical sushi protein | 0.019 | 0.0791 | 1 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0098 | 0.0093 | 0.0309 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.075 | 0.2089 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Brugia malayi | GCC2 and GCC3 family protein | 0.02 | 0.087 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.0025 | 0.0033 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.1499 | 0.4211 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Brugia malayi | pregnancy-associated plasma protein-A | 0.019 | 0.0791 | 0.0779 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Echinococcus granulosus | laminin | 0.0282 | 0.1499 | 0.7127 |
Plasmodium vivax | apical sushi protein, putative | 0.019 | 0.0791 | 1 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Loa Loa (eye worm) | ACC-1 protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1608 | 0.4519 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | ACC-1 protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0297 | 0.1608 | 0.6144 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | egf-like domain protein | 0.0282 | 0.1499 | 0.5726 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.0073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0098 | 0.0093 | 0.008 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | LGC-31 protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1946 | 0.5477 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0236 | 0.1142 | 0.4348 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0236 | 0.1142 | 0.113 |
Echinococcus granulosus | nAChR subunit | 0.0098 | 0.0093 | 0.0385 |
Entamoeba histolytica | hypothetical protein | 0.0098 | 0.0093 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Onchocerca volvulus | 0.0098 | 0.0093 | 0.0402 | |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.1608 | 0.4519 |
Onchocerca volvulus | 0.0267 | 0.1379 | 0.6842 | |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | Fibulin-1 precursor | 0.0282 | 0.1499 | 0.1488 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | nAChR subunit | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1946 | 0.5477 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0165 | 0.0602 | 0.1077 |
Echinococcus multilocularis | nAChR subunit | 0.0165 | 0.0602 | 0.1077 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0428 | 0.2609 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0361 | 0.2099 | 1 |
Onchocerca volvulus | 0.0165 | 0.0602 | 0.2952 | |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Echinococcus granulosus | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0805 | 0.5484 | 1 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.0551 | 0.3543 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.0073 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0297 | 0.1608 | 0.2915 |
Brugia malayi | Trypsin family protein | 0.0349 | 0.201 | 0.1999 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.3198 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.2063 |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.019 | 0.0791 | 0.5235 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.0073 | 1 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0633 | 0.1755 |
Onchocerca volvulus | Putative cubilin | 0.0089 | 0.0025 | 0.0058 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.1499 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0282 | 0.1499 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 0.2093 | 0.5892 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0165 | 0.0602 | 0.059 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0236 | 0.1142 | 0.2063 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0304 | 0.1665 | 0.4679 |
Loa Loa (eye worm) | hypothetical protein | 0.0349 | 0.201 | 0.5657 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus multilocularis | serotonin receptor | 0.0297 | 0.1608 | 0.2915 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0165 | 0.0602 | 0.1077 |
Echinococcus granulosus | C type lectin domian containing protein | 0.019 | 0.0791 | 0.3731 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.036 | 0.2093 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0236 | 0.1142 | 0.5412 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0282 | 0.1499 | 0.1488 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0165 | 0.0602 | 0.059 |
Leishmania major | C-8 sterol isomerase-like protein | 0.036 | 0.2093 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.227 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0165 | 0.0602 | 0.1077 |
Brugia malayi | Cation transporter family protein | 0.0165 | 0.0602 | 0.059 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.1077 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Echinococcus granulosus | c4b binding protein beta chain | 0.019 | 0.0791 | 0.3731 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.019 | 0.0791 | 0.2997 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.036 | 0.2093 | 0.5 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0098 | 0.0093 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Onchocerca volvulus | 0.019 | 0.0791 | 0.3897 | |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0341 | 0.1946 | 0.1936 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0236 | 0.1142 | 0.4348 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0165 | 0.0602 | 0.059 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Onchocerca volvulus | 0.0236 | 0.1142 | 0.5653 | |
Echinococcus multilocularis | c4b binding protein beta chain | 0.019 | 0.0791 | 0.1422 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0361 | 0.2099 | 0.8034 |
Echinococcus multilocularis | nAChR subunit | 0.0098 | 0.0093 | 0.0147 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0297 | 0.1608 | 0.7647 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | Sushi domain | 0.019 | 0.0791 | 0.0779 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.019 | 0.0791 | 0.5235 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0236 | 0.1142 | 0.5412 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.019 | 0.0791 | 0.2204 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0098 | 0.0093 | 0.0309 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.2826 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.087 | 0.2426 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0093 | 0.0227 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0165 | 0.0602 | 0.059 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 0.0791 | 0.2204 |
Echinococcus multilocularis | laminin | 0.0282 | 0.1499 | 0.2717 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0098 | 0.0093 | 0.008 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.1077 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0089 | 0.0025 | 0.0012 |
Onchocerca volvulus | 0.0349 | 0.201 | 1 | |
Onchocerca volvulus | Putative nachr subunit | 0.0236 | 0.1142 | 0.5653 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0165 | 0.0602 | 0.2826 |
Onchocerca volvulus | 0.0098 | 0.0093 | 0.0402 | |
Schistosoma mansoni | nAChR subunit | 0.0165 | 0.0602 | 0.227 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.036 | 0.2093 | 0.2082 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0165 | 0.0602 | 0.2826 |
Brugia malayi | hypothetical protein | 0.019 | 0.0791 | 0.0779 |
Brugia malayi | Cation transporter family protein | 0.0165 | 0.0602 | 0.059 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0361 | 0.2099 | 0.5909 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0361 | 0.2099 | 0.3812 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0165 | 0.0602 | 0.167 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0165 | 0.0602 | 0.1077 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0236 | 0.1142 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.2099 | 0.5909 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0602 | 0.167 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0341 | 0.1946 | 0.7447 |
Loa Loa (eye worm) | hypothetical protein | 0.0282 | 0.1499 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1142 | 0.3198 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0165 | 0.0602 | 0.167 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli W3110 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli W3110 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 | ChEMBL. | 17149863 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli pTMV19 in presence of mevalonate | ChEMBL. | 17149863 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.