Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Monoamine oxidase A | Starlite/ChEMBL | References |
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Bos taurus | Monoamine oxidase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase A | 527 aa | 542 aa | 21.6 % |
Brugia malayi | amine oxidase, flavin-containing family protein | Monoamine oxidase A | 527 aa | 472 aa | 21.4 % |
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase A | 527 aa | 552 aa | 18.5 % |
Onchocerca volvulus | Mitochondrial fission process protein 1 homolog | Monoamine oxidase B | 520 aa | 454 aa | 21.4 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase A | 527 aa | 546 aa | 21.6 % |
Dictyostelium discoideum | amine oxidase | Monoamine oxidase A | 527 aa | 492 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0404 | 0.204 | 0.6412 |
Brugia malayi | Fibulin-1 precursor | 0.0345 | 0.1337 | 0.6552 |
Echinococcus multilocularis | laminin | 0.0345 | 0.1337 | 0.5394 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0345 | 0.1337 | 0.6552 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1337 | 0.2556 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0345 | 0.1337 | 0.6552 |
Echinococcus multilocularis | fibrillin 1 | 0.0345 | 0.1337 | 0.5394 |
Echinococcus granulosus | laminin | 0.0345 | 0.1337 | 0.5394 |
Onchocerca volvulus | 0.0404 | 0.204 | 1 | |
Plasmodium vivax | apical sushi protein, putative | 0.0232 | 0 | 0.5 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0441 | 0.2479 | 0.7789 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.014 | 0.0267 |
Onchocerca volvulus | Arrow homolog | 0.0345 | 0.1337 | 0.6552 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.2479 | 0.4739 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1337 | 0.2556 |
Onchocerca volvulus | 0.0306 | 0.087 | 0.4264 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0345 | 0.1337 | 1 |
Plasmodium falciparum | apical sushi protein | 0.0232 | 0 | 0.5 |
Schistosoma mansoni | egf-like domain protein | 0.0345 | 0.1337 | 0.4201 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0244 | 0.014 | 0.0685 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1076 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.204 | 0.3901 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0345 | 0.1337 | 0.2556 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0441 | 0.2479 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0345 | 0.1337 | 0.2556 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1 | 0.9102 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0501 | 0.3182 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0441 | 0.2479 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0673 | 0.523 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0441 | 0.2479 | 0.4739 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0345 | 0.1337 | 1 |
Brugia malayi | Trypsin family protein | 0.0404 | 0.204 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.204 | 0.3901 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1337 | 0.2556 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 99.9 % | Antifungal activity against Candida albicans 1504 assessed as reduction in viability at 4 times MIC after 6 hrs by time kill assay | ChEMBL. | 26771245 |
IC50 (binding) | = 4.31 | Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay | ChEMBL. | 20579890 |
IC50 (binding) | = 6.93 | Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay | ChEMBL. | 20579890 |
IC50 (binding) | = 116 nM | Inhibition of human recombinant MAOB expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay | ChEMBL. | 20579890 |
IC50 (binding) | = 48351 nM | Inhibition of human recombinant MAOA expressed in baculovirus infected BTI-TN-5B1-4 insect cells assessed as hydrogen peroxide production from p-tyramine by amplex red assay | ChEMBL. | 20579890 |
Ki (binding) | = -7.69 | Inhibition of bovine brain mitochondria MAOA | ChEMBL. | 17253676 |
Ki (binding) | = -7.04 | Inhibition of bovine brain mitochondria MAOB | ChEMBL. | 17253676 |
Log Ki (binding) | = 7.04 | Inhibition of bovine brain mitochondria MAOB | ChEMBL. | 17253676 |
Log Ki (binding) | = 7.69 | Inhibition of bovine brain mitochondria MAOA | ChEMBL. | 17253676 |
Selectivity index (binding) | = 0.65 | Selectivity index, pKi for MAOA/pKi for MAOB | ChEMBL. | 17253676 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.