Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Trypsin family protein | 0.0414 | 0.4203 | 1 |
Onchocerca volvulus | 0.0315 | 0.1935 | 0.4603 | |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0342 | 0.2566 | 0.6106 |
Echinococcus granulosus | laminin | 0.0342 | 0.2566 | 0.5407 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0242 | 0.0277 | 0.066 |
Onchocerca volvulus | Arrow homolog | 0.0342 | 0.2566 | 0.6106 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0342 | 0.2566 | 0.6106 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0342 | 0.2566 | 0.2566 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.2566 | 0.2566 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0438 | 0.4746 | 0.4746 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.4203 | 0.4203 |
Echinococcus multilocularis | fibrillin 1 | 0.0342 | 0.2566 | 0.5407 |
Brugia malayi | Fibulin-1 precursor | 0.0342 | 0.2566 | 0.6106 |
Plasmodium vivax | apical sushi protein, putative | 0.023 | 0 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0438 | 0.4746 | 1 |
Onchocerca volvulus | 0.0414 | 0.4203 | 1 | |
Echinococcus multilocularis | laminin | 0.0342 | 0.2566 | 0.5407 |
Loa Loa (eye worm) | hypothetical protein | 0.0438 | 0.4746 | 0.4746 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0438 | 0.4746 | 0.7436 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0342 | 0.2566 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0438 | 0.4746 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0342 | 0.2566 | 0.4021 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0342 | 0.2566 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0277 | 0.0277 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0509 | 0.6383 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0414 | 0.4203 | 0.6585 |
Plasmodium falciparum | apical sushi protein | 0.023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.2566 | 0.2566 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.4203 | 0.4203 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0342 | 0.2566 | 0.2566 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.2566 | 0.2566 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Cytotoxicity against Vero cells upto 25 ug/mL by neutral red assay | ChEMBL. | 17253859 |
Activity (ADMET) | 0 | Cytotoxicity against LLC-PK1 cells upto 25 ug/mL by neutral red assay | ChEMBL. | 17253859 |
Activity (ADMET) | 0 | Cytotoxicity against SK-MEL cells upto 25 ug/mL by neutral red assay | ChEMBL. | 17253859 |
Activity (ADMET) | 0 | Cytotoxicity against KB cells upto 25 ug/mL by neutral red assay | ChEMBL. | 17253859 |
Activity (ADMET) | 0 | Cytotoxicity against BT549 cells upto 25 ug/mL by neutral red assay | ChEMBL. | 17253859 |
Activity (ADMET) | 0 | Cytotoxicity against SKOV3 cells upto 25 ug/mL by neutral red assay | ChEMBL. | 17253859 |
Activity (functional) | 0 | Antioxidant activity in HL60 cells by DCFH-DA method upto 20ug/mL | ChEMBL. | 17253859 |
Activity (binding) | 0 | Inhibition of activation of human complement | ChEMBL. | 17253859 |
Activity (binding) | 0 | Activity against human ERalpha expressed in recombinant yeast cells upto 500 ug/mL | ChEMBL. | 17253859 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.