Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0199 | 0.6012 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0135 | 0.2831 | 0.5392 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0162 | 0.4144 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.6012 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1379 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1379 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.1379 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 1 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0184 | 0.5251 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 1 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.1379 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.1379 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1379 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0199 | 0.6012 | 1 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0146 | 0.3383 | 0.8166 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1379 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | Inhibition of PDF2 | ChEMBL. | 17201406 |
IC50 (binding) | = 2 uM | Inhibition of PDF1B | ChEMBL. | 17201406 |
IC50 (binding) | = 2 uM | Inhibition of PDF1B | ChEMBL. | 17201406 |
IC50 (binding) | = 700 uM | Inhibition of human mitochondrial PDF | ChEMBL. | 17201406 |
IC50 (binding) | = 700 uM | Inhibition of human mitochondrial PDF | ChEMBL. | 17201406 |
IC50 (binding) | > 1000 uM | Inhibition of Arabidopsis thaliana mitochondrial PDF1A | ChEMBL. | 17201406 |
IC50 (binding) | > 1000 uM | Inhibition of Arabidopsis thaliana mitochondrial PDF1A | ChEMBL. | 17201406 |
MIC (functional) | Antibacterial activity against Escherichia coli JM101Tr | ChEMBL. | 17201406 | |
MIC (functional) | 0 | Antibacterial activity against Escherichia coli JM101Tr | ChEMBL. | 17201406 |
MIC (functional) | 0 | Antibacterial activity against Bacillus subtilis | ChEMBL. | 17201406 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.