Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0694 | 0.5 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0694 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0694 | 0.5 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0694 | 0.5 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0694 | 0.5 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0694 | 0.5 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0694 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 3.04 % | Binding affinity for dihydrofolate reductase from Lactobacillus casei | ChEMBL. | 9379435 |
Activity (binding) | = 3.04 % | Binding affinity for dihydrofolate reductase from Lactobacillus casei | ChEMBL. | 9379435 |
clogP | = 0.257 | Calculated partition coefficient (clogP) | ChEMBL. | 8941396 |
IC50 (binding) | = 2.78 | Compound was tested for inhibition of E. coli Dihydrofolate reductase. | ChEMBL. | 8941396 |
Ki (binding) | = 3.04 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
Log (binding) | = 2.78 1/IC50 | Compound was tested for inhibition of E. coli Dihydrofolate reductase. | ChEMBL. | 8941396 |
Log 1/Ki app (binding) | = 3.38 | Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log 1/Ki app (binding) | = 3.39 | Inhibitory activity against bovine liver Dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log 1/Ki app (binding) | = 3.04 | Apparent inhibitory (log 1/Ki) activity against Escherichia coli dihydrofolate reductase | ChEMBL. | 3276891 |
Log 1/Ki app (binding) | = 3.04 | Inhibitory activity against dihydrofolate reductase (DHFR) from Escherichia coli (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log 1/Ki app (binding) | = 3.38 | Inhibitory activity against dihydrofolate reductase (DHFR) from Lactobacillus casei (expressed as log 1/Kiapp) | ChEMBL. | 6809941 |
Log 1/Ki app (binding) | = 3.39 | Inhibitory activity against bovine liver Dihydrofolate reductase at pH 7.2. | ChEMBL. | 7069722 |
Log Ki (binding) | = 3.04 | Inhibition constant against binding of E. coli dihydrofolate reductase | ChEMBL. | 3290487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
6 literature references were collected for this gene.