Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | kinesin-5 | 0.0628 | 0.1284 | 0.5 |
Schistosoma mansoni | kinesin eg-5 | 0.0628 | 0.1284 | 0.1476 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0628 | 0.1284 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.4209 | 0.8699 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0012 | 0.0008 | 0.0008 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0056 | 0.0099 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.0252 | 0.1966 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.0252 | 0.1294 |
Chlamydia trachomatis | glycogen phosphorylase | 0.013 | 0.0252 | 0.5 |
Entamoeba histolytica | kinesin, putative | 0.0628 | 0.1284 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0008 | 0.0064 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0066 | 0.26 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.0252 | 0.0252 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.0252 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.0252 | 0.0252 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.004 | 0.0066 | 0.26 |
Giardia lamblia | Kinesin-5 | 0.0628 | 0.1284 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0012 | 0.0008 | 0.0008 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.0252 | 0.0252 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0056 | 0.0099 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0008 | 0.0009 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0012 | 0.0008 | 0.0009 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.0252 | 0.029 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0012 | 0.0008 | 0.0064 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0628 | 0.1284 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0071 | 0.0557 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.0252 | 0.0252 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.008 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.006 | 0.0465 |
Echinococcus multilocularis | kinesin family 1 | 0.4838 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.008 | 0.0092 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0012 | 0.0008 | 0.0008 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.0252 | 0.0252 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.0252 | 0.0252 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.0099 | 0.0114 |
Brugia malayi | Kinesin motor domain containing protein | 0.0628 | 0.1284 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0012 | 0.0008 | 0.0008 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.0252 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.0252 | 0.1966 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.0252 | 0.029 |
Plasmodium vivax | kinesin-5 | 0.0628 | 0.1284 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.013 | 0.0252 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0071 | 0.0557 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0071 | 0.0071 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.0252 | 0.1294 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0071 | 0.0071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 31 nM | Inhibition of recombinant human liver GPa by multienzyme coupled assay | ChEMBL. | 16945526 |
IC50 (binding) | = 31 nM | Inhibition of recombinant human liver GPa by multienzyme coupled assay | ChEMBL. | 16945526 |
IC50 (functional) | = 1.6 uM | Inhibition of glucose output in glucagon challenged rat hepatocytes | ChEMBL. | 16945526 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.