Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0602 | 0.3859 | 0.3859 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.036 | 0.18 | 0.18 |
Schistosoma mansoni | serine-rich repeat protein | 0.0311 | 0.1382 | 0.3785 |
Treponema pallidum | methyl-accepting chemotaxis protein (mcp2-1) | 0.1226 | 0.9167 | 0.5 |
Brugia malayi | Prenyltransferase and squalene oxidase repeat family protein | 0.0185 | 0.0311 | 0.3097 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0185 | 0.0311 | 0.0851 |
Echinococcus multilocularis | geranylgeranyl transferase type I beta subunit | 0.0185 | 0.0311 | 0.0311 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0291 | 0.1213 | 0.3323 |
Schistosoma mansoni | geranylgeranyl transferase type I beta subunit | 0.0185 | 0.0311 | 0.0851 |
Entamoeba histolytica | geranylgeranyl transferase beta subunit | 0.0185 | 0.0311 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0311 | 0.1382 | 0.3785 |
Loa Loa (eye worm) | prenyltransferase and squalene oxidase repeat family protein | 0.0185 | 0.0311 | 0.3097 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0149 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0266 | 0.1004 | 1 |
Echinococcus granulosus | geranylgeranyl transferase type I beta subunit | 0.0185 | 0.0311 | 0.0311 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.036 | 0.18 | 0.18 |
Trichomonas vaginalis | geranylgeranyl transferase type I beta subunit, putative | 0.0185 | 0.0311 | 1 |
Schistosoma mansoni | dihydropyridine-sensitive l-type calcium channel | 0.0577 | 0.365 | 1 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0149 | 0 | 0.5 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0149 | 0 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0602 | 0.3859 | 0.3859 |
Brugia malayi | Cache domain containing protein | 0.0266 | 0.1004 | 1 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.1323 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 64 % | Increase in human PXR activation expressed in CHO cells relative to rifampicin | ChEMBL. | 16950620 |
Activity (binding) | = 64 % | Increase in human PXR activation expressed in CHO cells relative to rifampicin | ChEMBL. | 16950620 |
IC50 (binding) | = 10 nM | Displacement of [125I]neurokinin B from cloned human NK3 receptor expressed in CHO cells | ChEMBL. | 16950620 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.