Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | 0 | Protein binding in rat plasma | ChEMBL. | 16987661 |
IC50 (binding) | = 0.7 nM | Binding affinity to human GR | ChEMBL. | 16987661 |
IC50 (binding) | = 0.7 nM | Binding affinity to human GR | ChEMBL. | 16987661 |
IC50 (binding) | = 4.2 nM | Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assay | ChEMBL. | 16987661 |
IC50 (binding) | = 4.2 nM | Activity at GR expressed in CHO cells assessed as decrease in dexamethasone-stimulated alkaline phosphatase production by GRAF assay | ChEMBL. | 16987661 |
Stabilty (ADMET) | = 96 % | Stability in rat liver microsomes after 20 mins | ChEMBL. | 16987661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.