Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.8819 | 0.8772 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.5528 | 0.5351 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0144 | 0.9683 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0094 | 0.5211 | 1 |
Brugia malayi | POT family protein | 0.0041 | 0.0381 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.2 uM | Inhibition of lipoprotein-associated phospholipase A2 in whole human plasma | ChEMBL. | 16919943 |
Inhibition (binding) | = 58 % | Inhibition of lipoprotein-associated phospholipase A2 in whole human plasma at 10 uM | ChEMBL. | 16919943 |
Inhibition (binding) | = 98 % | Inhibition of lipoprotein-associated phospholipase A2 in whole human plasma at 10 uM | ChEMBL. | 16919943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.