Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Seizure activity in anesthetized rat at 15 mg/kg, iv | ChEMBL. | 17298049 |
BPR (ADMET) | = 1.1 | Ratio of drug level in rat brain against plasma | ChEMBL. | 17298049 |
Cp (ADMET) | = 32 ug ml-1 | Plasma drug concentration in iv dosed inactin-anesthetized Sprague-Dawley rat in prematurely terminated hemodynamic study | ChEMBL. | 17298049 |
IC50 (binding) | > 30 uM | Inhibition of human recombinant ACC1 expressed in HEK293 cells | ChEMBL. | 17298049 |
IC50 (binding) | > 30 uM | Inhibition of human recombinant ACC2 expressed in SF9 cells | ChEMBL. | 17298049 |
IC50 (binding) | > 30 uM | Inhibition of ACC1 | ChEMBL. | 17234407 |
IC50 (binding) | > 30 uM | Inhibition of ACC2 | ChEMBL. | 17234407 |
IC50 (binding) | > 30 uM | Inhibition of human recombinant ACC1 expressed in HEK293 cells | ChEMBL. | 17298049 |
IC50 (binding) | > 30 uM | Inhibition of human recombinant ACC2 expressed in SF9 cells | ChEMBL. | 17298049 |
IC50 (binding) | > 30 uM | Inhibition of ACC1 | ChEMBL. | 17234407 |
IC50 (binding) | > 30 uM | Inhibition of ACC2 | ChEMBL. | 17234407 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.