Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | selectin P (granule membrane protein 140kDa, antigen CD62) | Starlite/ChEMBL | References |
Homo sapiens | selectin E | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | c4b binding protein beta chain | selectin E | 610 aa | 551 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Echinococcus multilocularis | c4b binding protein beta chain | 0.0033 | 0 | 0.5 |
Toxoplasma gondii | rhoptry neck protein RON9 | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | c4b binding protein beta chain | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | C type lectin domian containing protein | 0.0033 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.4835 | 0.4835 |
Plasmodium falciparum | apical sushi protein | 0.0033 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Toxoplasma gondii | rhoptry neck protein RON1 | 0.0033 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Plasmodium vivax | apical sushi protein, putative | 0.0033 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 1 | 1 |
Echinococcus granulosus | C type lectin domian containing protein | 0.0033 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.7 uM | Inhibition of human E-selectin after 2 hrs | ChEMBL. | 17302397 |
IC50 (binding) | = 8.7 uM | Inhibition of human E-selectin after 2 hrs | ChEMBL. | 17302397 |
IC50 (binding) | = 14.8 uM | Inhibition of human P-selectin after 2 hrs | ChEMBL. | 17302397 |
IC50 (binding) | = 14.8 uM | Inhibition of human P-selectin after 2 hrs | ChEMBL. | 17302397 |
IC50 (binding) | = 26.2 uM | Inhibition of human L-selectin after 2 hrs | ChEMBL. | 17302397 |
IC50 (binding) | = 26.2 uM | Inhibition of human L-selectin after 2 hrs | ChEMBL. | 17302397 |
Inhibition (functional) | = 16 % | Inhibition of attachment of HL60 cells to E-selectin at 109 uM after 5 mins | ChEMBL. | 17302397 |
Inhibition (functional) | = 16 % | Inhibition of attachment of HL60 cells to E-selectin at 109 uM after 5 mins | ChEMBL. | 17302397 |
Inhibition (functional) | = 20 % | Inhibition of attachment of HL60 cells to P-selectin at 109 uM after 5 mins | ChEMBL. | 17302397 |
Inhibition (functional) | = 20 % | Inhibition of attachment of HL60 cells to P-selectin at 109 uM after 5 mins | ChEMBL. | 17302397 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.