Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Muscle positioning protein 4 | 0.1539 | 0.65 | 0.2758 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.1984 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1984 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.1984 | 1 | 0.5 |
Onchocerca volvulus | 0.1539 | 0.65 | 0.2758 | |
Loa Loa (eye worm) | hypothetical protein | 0.1369 | 0.5168 | 0.4399 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.1984 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1539 | 0.65 | 0.5943 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1984 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1369 | 0.5168 | 0.5168 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.1369 | 0.5168 | 0.4399 |
Loa Loa (eye worm) | hypothetical protein | 0.1984 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.1984 | 1 | 0.5 |
Onchocerca volvulus | 0.1984 | 1 | 1 | |
Brugia malayi | Kringle domain containing protein | 0.1984 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.1984 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0961 | 0.196 | 0.196 |
Leishmania major | hypothetical protein, conserved | 0.1984 | 1 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.1984 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | Antimicrobial activity against vancomycin-sensitive Enterococcus faecalis ATCC 29212 by broth microdilution method | ChEMBL. | 17323996 |
MIC (functional) | = 4 ug ml-1 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus Smith ATCC 19636 by tube dilution method | ChEMBL. | 17323996 |
MIC (functional) | = 4 ug ml-1 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 by broth microdilution method | ChEMBL. | 17323996 |
MIC (functional) | = 4 ug ml-1 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis ATCC 51625 by broth microdilution method | ChEMBL. | 17323996 |
MIC (functional) | = 4 ug ml-1 | Antimicrobial activity against methicillin-sensitive Staphylococcus aureus Smith ATCC 19636 by broth microdilution method | ChEMBL. | 17323996 |
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus CDC HIP 5836 by broth microdilution method | ChEMBL. | 17323996 |
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against vancomycin/multidrug-resistant Enterococcus faecium ATCC 51559 by broth microdilution method | ChEMBL. | 17323996 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.