Species | Target name | Source | Bibliographic reference |
---|---|---|---|
SARS coronavirus | SARS coronavirus 3C-like proteinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.2782 | 0.6713 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.2782 | 0.6713 | 0.5 |
Echinococcus granulosus | Mastin | 0.0883 | 0.0688 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0323 | 0.0343 |
Onchocerca volvulus | 0.0768 | 0.0323 | 0.0343 | |
Onchocerca volvulus | 0.0682 | 0.0048 | 0.0051 | |
Toxoplasma gondii | PAN domain-containing protein | 0.1504 | 0.2659 | 0.3961 |
Brugia malayi | hypothetical protein | 0.0768 | 0.0323 | 0.0343 |
Onchocerca volvulus | 0.0768 | 0.0323 | 0.0343 | |
Loa Loa (eye worm) | hypothetical protein | 0.0682 | 0.0048 | 0.0051 |
Brugia malayi | Trypsin family protein | 0.0768 | 0.0323 | 0.0343 |
Leishmania major | hypothetical protein, conserved | 0.2782 | 0.6713 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.2782 | 0.6713 | 0.7121 |
Echinococcus granulosus | enteropeptidase | 0.0883 | 0.0688 | 0.057 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0768 | 0.0323 | 0.0343 |
Brugia malayi | Protein kinase domain containing protein | 0.2782 | 0.6713 | 0.7121 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0883 | 0.0688 | 0.0377 |
Echinococcus granulosus | tissue type plasminogen activator | 0.2782 | 0.6713 | 1 |
Onchocerca volvulus | 0.2782 | 0.6713 | 0.7121 | |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0323 | 0.0343 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.086 | 0.0613 | 0.03 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.2782 | 0.6713 | 0.7121 |
Brugia malayi | Muscle positioning protein 4 | 0.0682 | 0.0048 | 0.0051 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.2782 | 0.6713 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.2782 | 0.6713 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.2782 | 0.6713 | 0.6603 |
Onchocerca volvulus | 0.3637 | 0.9427 | 1 | |
Onchocerca volvulus | 0.2869 | 0.6989 | 0.7414 | |
Brugia malayi | Trypsin family protein | 0.3637 | 0.9427 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0323 | 0.0343 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.3637 | 0.9427 | 0.9407 |
Echinococcus multilocularis | Mastin | 0.0883 | 0.0688 | 0.057 |
Onchocerca volvulus | 0.0768 | 0.0323 | 0.0343 | |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0883 | 0.0688 | 0.057 |
Toxoplasma gondii | PAN domain-containing protein | 0.1504 | 0.2659 | 0.3961 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0883 | 0.0688 | 0.057 |
Brugia malayi | Trypsin-like protease protein 5 | 0.0768 | 0.0323 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0323 | 0.0343 |
Onchocerca volvulus | 0.0768 | 0.0323 | 0.0343 | |
Brugia malayi | Trypsin family protein | 0.0768 | 0.0323 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 0.9427 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0883 | 0.0688 | 0.057 |
Onchocerca volvulus | 0.0768 | 0.0323 | 0.0343 | |
Toxoplasma gondii | kringle domain-containing protein | 0.2782 | 0.6713 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.0768 | 0.0323 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.0768 | 0.0323 | 0.0343 |
Loa Loa (eye worm) | hypothetical protein | 0.2782 | 0.6713 | 0.7121 |
Brugia malayi | Trypsin family protein | 0.0768 | 0.0323 | 0.0343 |
Mycobacterium ulcerans | hypothetical protein | 0.0768 | 0.0323 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3637 | 0.9427 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 170 nM | Inhibition of SARS coronavirus 3C-like protease | ChEMBL. | 17381079 |
IC50 (binding) | = 170 nM | Inhibition of SARS coronavirus 3C-like protease | ChEMBL. | 17381079 |
Inhibition (binding) | = 94 % | Inhibition of SARS coronavirus His-3C-like protease at 100 uM | ChEMBL. | 17381079 |
Inhibition (binding) | = 94 % | Inhibition of SARS coronavirus His-3C-like protease at 100 uM | ChEMBL. | 17381079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.