Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | transient receptor potential cation channel | 0.0006 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0006 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0006 | 0.5 | 0.5 |
Schistosoma mansoni | transient receptor potential channel | 0.0006 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0006 | 0.5 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0006 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0006 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.5 | 0.5 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0006 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 43 % | Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production at 10 uM | ChEMBL. | 17378544 |
Activity (functional) | = 43 % | Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production at 10 uM | ChEMBL. | 17378544 |
Efficacy (functional) | = 0 % | Maximum efficacy at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP production at 10 uM relative to NECA | ChEMBL. | 17378544 |
Efficacy (functional) | = 0 % | Maximum efficacy at human recombinant adenosine A3 receptor expressed in CHO cells assessed as inhibition of cAMP production at 10 uM relative to NECA | ChEMBL. | 17378544 |
Inhibition (binding) | = 39 % | Displacement of [3H]CPPA from human adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 17378544 |
Inhibition (binding) | = 39 % | Displacement of [3H]CPPA from human adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 17378544 |
Ki (binding) | = 1340 nM | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 17378544 |
Ki (binding) | = 1340 nM | Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 17378544 |
Ki (binding) | = 2670 nM | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 17378544 |
Ki (binding) | = 2670 nM | Displacement of [3H]CGS21680 from human adenosine A2A receptor expressed in CHO cells | ChEMBL. | 17378544 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.