Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0222 | 0.4297 | 0.4297 |
Onchocerca volvulus | 0.0126 | 0 | 0.5 | |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0194 | 0.306 | 0.306 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0253 | 0.5703 | 0.5703 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0222 | 0.4297 | 0.4297 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0349 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0349 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0222 | 0.4297 | 0.4297 |
Brugia malayi | Variant SH3 domain containing protein | 0.0194 | 0.306 | 0.306 |
Schistosoma mansoni | tyrosine kinase | 0.0222 | 0.4297 | 0.4297 |
Onchocerca volvulus | 0.0126 | 0 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0349 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0349 | 1 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0194 | 0.306 | 0.306 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0226 | 0.4466 | 0.4466 |
Schistosoma mansoni | tyrosine kinase | 0.0349 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0349 | 1 | 1 |
Onchocerca volvulus | 0.0126 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0349 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0349 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0155 | 0.1296 | 0.1296 |
Echinococcus granulosus | c src tyrosine kinase | 0.0222 | 0.4297 | 0.4297 |
Echinococcus granulosus | NCK adaptor protein | 0.0194 | 0.306 | 0.306 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0194 | 0.306 | 0.306 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0349 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0253 | 0.5703 | 0.5703 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0349 | 1 | 1 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0194 | 0.306 | 0.306 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0194 | 0.306 | 0.306 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0253 | 0.5703 | 0.5703 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0349 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0349 | 1 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.0194 | 0.306 | 0.306 |
Schistosoma mansoni | tyrosine kinase | 0.0349 | 1 | 1 |
Schistosoma mansoni | nck2/grb4 | 0.0194 | 0.306 | 0.306 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0349 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0222 | 0.4297 | 0.4297 |
Loa Loa (eye worm) | TK protein kinase | 0.0155 | 0.1296 | 0.1296 |
Brugia malayi | protein-tyrosine kinase | 0.0253 | 0.5703 | 0.5703 |
Schistosoma mansoni | adapter molecule crk | 0.0194 | 0.306 | 0.306 |
Loa Loa (eye worm) | TK protein kinase | 0.0253 | 0.5703 | 0.5703 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0253 | 0.5703 | 0.5703 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.306 | 0.306 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0222 | 0.4297 | 0.4297 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0349 | 1 | 1 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0194 | 0.306 | 0.306 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0253 | 0.5703 | 0.5703 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0194 | 0.306 | 0.306 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0349 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.0349 | 1 | 1 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0194 | 0.306 | 0.306 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0155 | 0.1296 | 0.1296 |
Onchocerca volvulus | 0.0126 | 0 | 0.5 | |
Onchocerca volvulus | 0.0126 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0349 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0349 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0222 | 0.4297 | 0.4297 |
Onchocerca volvulus | 0.0126 | 0 | 0.5 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0222 | 0.4297 | 0.4297 |
Echinococcus granulosus | tyrosine kinase | 0.0253 | 0.5703 | 0.5703 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0349 | 1 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0194 | 0.306 | 0.306 |
Entamoeba histolytica | protein kinase, putative | 0.0155 | 0.1296 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0226 | 0.4466 | 0.4466 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 200 uM | Cytotoxicity against mouse L1210/0 cells after 48 hrs | ChEMBL. | 17341060 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.