Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.2616 | 0.2192 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.083 | 0.083 |
Brugia malayi | follicle stimulating hormone receptor | 0.0261 | 0.6031 | 0.6382 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 0.2616 | 0.2616 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0072 | 0.083 | 0.083 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0137 | 0.2616 | 0.2616 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0137 | 0.2616 | 0.2192 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0368 | 0.8978 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2616 | 0.2192 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0261 | 0.6031 | 0.6382 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0072 | 0.083 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0368 | 0.8978 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.083 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.083 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0368 | 0.8978 | 1 |
Echinococcus multilocularis | expressed protein | 0.0405 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0072 | 0.083 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0072 | 0.083 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0137 | 0.2616 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2616 | 0.2192 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0368 | 0.8978 | 0.8978 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 0.2616 | 0.2616 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0368 | 0.8978 | 0.8978 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0137 | 0.2616 | 0.2192 |
Brugia malayi | Carboxylesterase family protein | 0.0137 | 0.2616 | 0.2192 |
Echinococcus multilocularis | acetylcholinesterase | 0.0137 | 0.2616 | 0.2616 |
Echinococcus granulosus | carboxylesterase 5A | 0.0137 | 0.2616 | 0.2616 |
Loa Loa (eye worm) | carboxylesterase | 0.0137 | 0.2616 | 0.2192 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 2 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in G1 phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
Activity (functional) | = 2 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in S phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
Activity (functional) | = 2 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in G1 phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
Activity (functional) | = 2 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in S phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
Activity (functional) | = 12 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in G2+M phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
Activity (functional) | = 12 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in G2+M phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
Activity (functional) | = 84 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in 8N phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
Activity (functional) | = 84 % | Cell cycle perturbations in mouse L1210 cells assessed as accumulation in 8N phase after 21 hrs at 2 uM relative to control | ChEMBL. | 16279796 |
IC50 (functional) | = 0.41 uM | Antiproliferative activity against mouse L1210 cells after 48 hrs relative control | ChEMBL. | 16279796 |
IC50 (functional) | = 0.41 uM | Antiproliferative activity against mouse L1210 cells after 48 hrs relative control | ChEMBL. | 16279796 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 16279796 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.