Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 40 % | Increase in 16 ug/ml norfloxacin accumulation in Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml after 20 mins | ChEMBL. | 17101679 |
Drug uptake (functional) | = 270 ng/mg | Increase in 16 ug/ml norfloxacin accumulation in Staphylococcus aureus SA1199B mutant overexpressing NorA measured per milligram of cell protein at 128 ug/ml after 5 mins | ChEMBL. | 17101679 |
Drug uptake (functional) | = 400 ng/mg | Increase in 16 ug/ml norfloxacin accumulation in Staphylococcus aureus SA1199B mutant overexpressing NorA measured per milligram of cell protein at 128 ug/ml after 20 mins | ChEMBL. | 17101679 |
IZ (functional) | = 6 mm | Increase in 5 ug norfloxacin antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by disk diffusion method | ChEMBL. | 17101679 |
IZ (functional) | = 14 mm | Increase in 5 ug ciprofloxacin antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by disk diffusion method | ChEMBL. | 17101679 |
IZ (functional) | = 19 mm | Increase in 5 ug ofloxacin antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by disk diffusion method | ChEMBL. | 17101679 |
IZ (functional) | = 22 mm | Increase in 5 ug levofloxacin antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by disk diffusion method | ChEMBL. | 17101679 |
IZ (functional) | = 25 mm | Increase in 30 ug chloramphenicol antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by disk diffusion method | ChEMBL. | 17101679 |
IZ (functional) | = 27 mm | Increase in 5 ug sparfloxacin antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by disk diffusion method | ChEMBL. | 17101679 |
IZ (functional) | = 27 mm | Increase in 5 ug moxifloxacin antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by disk diffusion method | ChEMBL. | 17101679 |
MIC (functional) | = 2 ug ml-1 | Increase in 2 ug/ml norfloxacin antibacterial activity against wild type Staphylococcus aureus SA1199 at 128 ug/ml by checker board method | ChEMBL. | 17101679 |
MIC (functional) | = 32 ug ml-1 | Increase in 64 ug/ml norfloxacin antibacterial activity against Staphylococcus aureus SA1199B mutant overexpressing NorA at 128 ug/ml by checker board method | ChEMBL. | 17101679 |
MIC (functional) | > 512 ug ml-1 | Antibacterial activity against Staphylococcus aureus | ChEMBL. | 17101679 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.