Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1868 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1868 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1868 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 50 uM | Antileishmanial activity against Leishmania amazonensis MHOM/BR/1987/BA proamastigotes by MTT assay after 1 to 2 days | ChEMBL. | 17049253 |
IC50 (functional) | > 50 uM | Antileishmanial activity against Leishmania infantum clone MCAN/GR/82/LEM497 proamastigotes by MTT assay after 1 to 2 days | ChEMBL. | 17049253 |
IC50 (functional) | > 50 uM | Antileishmanial activity against Leishmania infantum clone MCAN/GR/82/LEM497 proamastigotes by MTT assay after 1 to 2 days | ChEMBL. | 17049253 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human PBMC by MTT assay after 3 to 4 days | ChEMBL. | 17049253 |
IC50 (ADMET) | = 100 uM | Cytotoxicity against human phytohaemagglutinin-activated-PBMC by MTT assay after 3 to 4 days | ChEMBL. | 17049253 |
IC50 (ADMET) | > 100 uM | Cytotoxicity against human PBMC by MTT assay after 3 to 4 days | ChEMBL. | 17049253 |
IC50 (ADMET) | = 100 uM | Cytotoxicity against human phytohaemagglutinin-activated-PBMC by MTT assay after 3 to 4 days | ChEMBL. | 17049253 |
Log D | = 3.35 | Partition coefficient, log D of the compound at pH 7.4 | ChEMBL. | 17049253 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.