Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0111 | 0.0249 | 0.1101 |
Echinococcus granulosus | carbonic anhydrase II | 0.0298 | 0.2264 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0111 | 0.0249 | 0.1101 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0298 | 0.2264 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Echinococcus granulosus | carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1016 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0298 | 0.2264 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0284 | 0.2112 | 0.0669 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.0249 | 0.1101 |
Onchocerca volvulus | 0.0203 | 0.1246 | 1 | |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0298 | 0.2264 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0111 | 0.0249 | 0.1101 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0111 | 0.0249 | 0.1101 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0298 | 0.2264 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0967 | 0.9472 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0111 | 0.0249 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0111 | 0.0249 | 0.1101 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0249 | 0.1101 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0235 | 0.1585 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0298 | 0.2264 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0203 | 0.1246 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0298 | 0.2264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0249 | 0.1101 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0298 | 0.2264 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0298 | 0.2264 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0111 | 0.0249 | 0.1101 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0298 | 0.2264 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0111 | 0.0249 | 0.1101 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1016 | 1 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0111 | 0.0249 | 0.1101 |
Plasmodium falciparum | carbonic anhydrase | 0.0111 | 0.0249 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.0298 | 0.2264 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0298 | 0.2264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0249 | 0.1101 |
Echinococcus granulosus | carbonic anhydrase | 0.0111 | 0.0249 | 0.1101 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 24.9 % | Inhibition of T-type calcium channel Cav3.1 with alpha1G subunit expressed in HEK293 cells at 100 uM by FDSS6000 assay | ChEMBL. | 17035033 |
Inhibition (binding) | = 24.9 % | Inhibition of T-type calcium channel Cav3.1 with alpha1G subunit expressed in HEK293 cells at 100 uM by FDSS6000 assay | ChEMBL. | 17035033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.