Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.008 ug ml-1 | Antibacterial activity against Staphylococcus aureus 209P JC1 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 0.031 ug ml-1 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae KK133 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 0.031 ug ml-1 | Antibacterial activity against Moraxella catarrhlis W-0500 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 0.063 ug ml-1 | Antibacterial activity against beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 870 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 0.125 ug ml-1 | Antibacterial activity against Escherichia coli NIHJ JC2 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 0.125 ug ml-1 | Antibacterial activity against Escherichia coli NIHJ JC2 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 0.25 ug ml-1 | Antibacterial activity against Klebsiella pneumoniae GN69 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 1 ug ml-1 | Antibacterial activity against methicillin-resistant Staphylococcus aureus M126 by agar dilution method | ChEMBL. | 17055731 |
MIC (functional) | = 4 ug ml-1 | Antibacterial activity against carbapenem and methicillin-resistant Staphylococcus aureus M126HR by agar dilution method | ChEMBL. | 17055731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.